J
Jorge Flores
Researcher at Howard Hughes Medical Institute
Publications - 6
Citations - 1374
Jorge Flores is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Antennal lobe & Dopamine. The author has an hindex of 5, co-authored 6 publications receiving 1241 citations. Previous affiliations of Jorge Flores include Columbia University.
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Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain
TL;DR: A sensitive imaging system in the Drosophila brain that couples two-photon microscopy with the specific expression of the calcium-sensitive fluorescent protein, G-CaMP is developed, demonstrating that the response pattern of a given glomerulus is a function of the specificity of a single odorant receptor.
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The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
Sandeep Robert Datta,Maria Luisa Vasconcelos,Vanessa Ruta,Sean Luo,Allan M. Wong,Allan M. Wong,Ebru Demir,Jorge Flores,Karen Balonze,Barry J. Dickson,Richard Axel +10 more
TL;DR: A neural tracing procedure that employs two-photon laser scanning microscopy to activate the photoactivatable green fluorescent protein is developed, showing that the projections from the DA1 glomerulus to the protocerebrum are sexually dimorphic.
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Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.
Zachary Freyberg,Mark S. Sonders,Jenny I. Aguilar,Takato Hiranita,Caline S. Karam,Jorge Flores,Andrea B. Pizzo,Yuchao Zhang,Zachary J. Farino,Audrey Chen,Ciara A. Martin,Theresa A. Kopajtic,Hao Fei,Gang Hu,Yi-Ying Lin,Eugene V. Mosharov,Brian D. McCabe,Robin Freyberg,Kandatege Wimalasena,Ling-Wei Hsin,Dalibor Sames,David E. Krantz,Jonathan L. Katz,David Sulzer,Jonathan A. Javitch +24 more
TL;DR: It is shown in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced locomotion and self-administration without impacting cocaine-induced behaviours.
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Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.
Jenny I. Aguilar,Matthew Dunn,Susana Mingote,Caline S. Karam,Zachary J. Farino,Mark S. Sonders,Se Joon Choi,Anna Grygoruk,Yuchao Zhang,Carolina Cela,Ben Jiwon Choi,Jorge Flores,Robin Freyberg,Brian D. McCabe,Eugene V. Mosharov,David E. Krantz,Jonathan A. Javitch,David Sulzer,Dalibor Sames,Stephen Rayport,Zachary Freyberg +20 more
TL;DR: It is shown that cell depolarization increases synaptic vesicle dopamine content prior to release via vesicular hyperacidification and its dependence on VGLUT2 are seen in ventral midbrain dopamine neurons in the mouse.
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Model for Transition from Waves to Synchrony in the Olfactory Lobe of Limax
TL;DR: A biophysical model for the interactions between bursting (B) cells and nonbursting (NB) cells in the procerebral lobe of Limax is developed and tested and a novel calcium current is suggested to explain the effects of nitric oxide (NO) on the lobe.