J
José I. Martín-Subero
Researcher at University of Kiel
Publications - 60
Citations - 4844
José I. Martín-Subero is an academic researcher from University of Kiel. The author has contributed to research in topics: Fluorescence in situ hybridization & DNA methylation. The author has an hindex of 34, co-authored 60 publications receiving 4545 citations. Previous affiliations of José I. Martín-Subero include Spanish National Research Council & Catalan Institution for Research and Advanced Studies.
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Journal ArticleDOI
A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling
Michael Hummel,Stefan Bentink,Hilmar Berger,Wolfram Klapper,Swen Wessendorf,Thomas F. E. Barth,Heinz Wolfram Bernd,Sergio Cogliatti,Judith Dierlamm,Alfred C. Feller,Martin-Leo Hansmann,Eugenia Haralambieva,Lana Harder,Dirk Hasenclever,Michael Kühn,Dido Lenze,Peter Lichter,José I. Martín-Subero,Peter Möller,Hans Konrad Müller-Hermelink,German Ott,Reza Parwaresch,Christiane Pott,Andreas Rosenwald,Maciej Rosolowski,Carsten Schwaenen,Benjamin Stürzenhofecker,Monika Szczepanowski,Heiko Trautmann,Hans Heinrich Wacker,Rainer Spang,Markus Loeffler,Lorenz Trümper,Harald Stein,Reiner Siebert +34 more
TL;DR: The molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt’s lymphoma.
Journal ArticleDOI
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
Roland Schmitz,Martin-Leo Hansmann,Verena Bohle,José I. Martín-Subero,Sylvia Hartmann,Gunhild Mechtersheimer,Wolfram Klapper,Inga Vater,Maciej Giefing,Maciej Giefing,Stefan Gesk,Jens Stanelle,Reiner Siebert,Ralf Küppers +13 more
TL;DR: TNFAIP3 (A20), a key regulator of NF-κB activity, is identified as a novel tumor suppressor gene in cHL and PMBL and the significantly higher frequency of TNFAIP 3 mutations in EBV− than EBV+ cHL suggests complementing functions of TN FAIP3 inactivation and EBV infection in c HL pathogenesis.
Journal ArticleDOI
A DNA methylation fingerprint of 1628 human samples
Augustin F. Fernandez,Yassen Assenov,José I. Martín-Subero,Balázs Bálint,Reiner Siebert,Hiroaki Taniguchi,Hiroyuki Yamamoto,Manuel Hidalgo,Manuel Hidalgo,Aik Choon Tan,Oliver Galm,Isidre Ferrer,Montse Sanchez-Cespedes,Alberto Villanueva,Javier Carmona,Jose V. Sanchez-Mut,María Berdasco,Victor Moreno,Gabriel Capellá,David Monk,Esteban Ballestar,Santiago Ropero,Ramon Martinez,Marta Sanchez-Carbayo,Felipe Prosper,Xabier Agirre,Mario F. Fraga,Mario F. Fraga,Osvaldo Graña,Luis A. Pérez-Jurado,Jaume Mora,Susana Puig,Jaime Prat,Lina Badimon,Annibale Alessandro Puca,Stephen J. Meltzer,Thomas Lengauer,John Bridgewater,Christoph Bock,Manel Esteller +39 more
TL;DR: The DNA methylation patterns identified across the largest spectrum of samples, tissues, and diseases reported to date constitute a baseline for developing higher-resolutionDNA methylation maps and provide important clues concerning the contribution of CpG methylation to tissue identity and its changes in the most prevalent human diseases.
Journal ArticleDOI
FISH Analysis for the Detection of Lymphoma-Associated Chromosomal Abnormalities in Routine Paraffin-Embedded Tissue
Roland Ventura,José I. Martín-Subero,Margaret Jones,Joanna McParland,Stefan Gesk,David Y. Mason,Reiner Siebert +6 more
TL;DR: Practical strategies for using FISH analysis to detect lymphoma-associated chromosomal abnormalities in routine paraffin-embedded lymphoma biopsies are described and proposals on how FISH results should be interpreted are provided.
Journal ArticleDOI
Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.
José I. Martín-Subero,Stefan Gesk,Lana Harder,Takashi Sonoki,Philip W. Tucker,Brigitte Schlegelberger,Werner Grote,Francisco J. Novo,María José Calasanz,Martin L. Hansmann,Martin J. S. Dyer,Reiner Siebert +11 more
TL;DR: Data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL, with signal patterns suggesting breakpoints in the region spanned by the REL probe.