Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE
Naohiro Inohara,Yasunori Ogura,Ana Fontalba,Olga Gutierrez,F. Pons,Javier Crespo,Koichi Fukase,Seiichi Inamura,Shoichi Kusumoto,Masahito Hashimoto,Simon J. Foster,Anthony P. Moran,Jose L. Fernandez-Luna,Gabriel Núñez +13 more
TLDR
NOD2 mediates the host response to bacterial muropeptides derived from peptidoglycan, an activity that is important for protection against Crohn's disease and has implications for understanding adjuvant function and effective vaccine development.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-02-21 and is currently open access. It has received 1652 citations till now. The article focuses on the topics: Muramyl dipeptide & NOD2.read more
Citations
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Toll-like receptors in innate immunity.
Kiyoshi Takeda,Shizuo Akira +1 more
TL;DR: Toll-like receptors-mediated activation of innate immunity controls not only host defense against pathogens but also immune disorders, and the involvement of TLR-mediated pathways in autoimmune and inflammatory diseases has been proposed.
Journal ArticleDOI
Regulation and Function of NF-κB Transcription Factors in the Immune System
TL;DR: Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review.
Journal ArticleDOI
Caspase Functions in Cell Death and Disease
TL;DR: Dysregulation of caspases underlies human diseases including cancer and inflammatory disorders, and major efforts to design better therapies for these diseases seek to understand how these enzymes work and how they can be controlled.
Journal ArticleDOI
Toll-like receptors and innate immunity
Satoshi Uematsu,Shizuo Akira +1 more
TL;DR: This review focuses on the functions of PRRs in innate immunity and their downstream signaling cascades and identifies cytoplasmic PRRs to detect pathogens that have invaded cytosols.
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The immunological and genetic basis of inflammatory bowel disease.
G. Bouma,G. Bouma,Warren Strober +2 more
TL;DR: The most important finding is the identification of mutations in the gene that encodes NOD2 (nucleotide-binding oligomerization domain 2) protein in a subgroup of patients with Crohn's disease.
References
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Journal ArticleDOI
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more
TL;DR: It is suggested that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn’s disease that can now be further investigated.
Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal ArticleDOI
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Osamu Takeuchi,Katsuaki Hoshino,Taro Kawai,Hideki Sanjo,Haruhiko Takada,Tomohiko Ogawa,Kiyoshi Takeda,Shizuo Akira +7 more
TL;DR: It is demonstrated that TLR2 and TLR4 recognize different bacterial cell wall components in vivo andTLR2 plays a major role in Gram-positive bacterial recognition.
Journal ArticleDOI
Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
Antonios O. Aliprantis,Ruey-Bing Yang,Melanie R. Mark,Shelly Suggett,Brigitte Devaux,Justin D. Radolf,Gary R. Klimpel,Paul J. Godowski,Arturo Zychlinsky +8 more
TL;DR: BLPs were found to induce apoptosis in THP-1 monocytic cells through human Toll-like receptor-2 (hTLR2), which is a molecular link between microbial products, apoptosis, and host defense mechanisms.
Journal ArticleDOI
Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB *
Yasunori Ogura,Naohiro Inohara,Adalberto Benito,Felicia F. Chen,Shoji Yamaoka,Shoji Yamaoka,Gabriel Núñez +6 more
TL;DR: A subfamily of Apaf-1-like proteins that function through RICK to activate a NF-κB signaling pathway is defined, which contains a caspase recruitment domain linked to a nucleotide-binding domain and multiple C-terminal leucine-rich repeats.
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Jean-Pierre Hugot,Mathias Chamaillard,Mathias Chamaillard,Habib Zouali,Suzanne Lesage,Jean-Pierre Cézard,Jacques Belaiche,Sven Almer,Curt Tysk,Colm O'Morain,Miquel A. Gassull,Vibeke Binder,Yigael Finkel,Antoine Cortot,Robert Modigliani,Pierre Laurent-Puig,C. Gower-Rousseau,J. Macry,Jean-Frederic Colombel,Mourad Sahbatou,Gilles Thomas,Gilles Thomas +21 more