Josef W. Goldufsky

TL;DR: It is reported that unadjuvanted seasonal influenza vaccination via intratumoral, but not intramuscular, injection converts “cold” tumors to hot, generates systemic CD8+ T cell-mediated antitumor immunity, and sensitizes resistant tumors to checkpoint blockade, and proposes that antipathogen vaccines may be utilized for both infection prevention and repurposing as a cancer immunotherapy.

TL;DR: It is demonstrated that the GAP domain activity is both necessary and sufficient to induce mitochondrial (intrinsic) apoptosis and is completely dependent on caspase-9 activity.

TL;DR: Data demonstrate that P. aeruginosa establishes a robust and persistent infection in diabetic wounds independent of its ability to form biofilm and causes severe wound damage in a manner that primarily depends on its T3SS.

TL;DR: It is demonstrated that a fraction of apoptotic cells produce and release CrkI-containing microvesicles, which induce proliferation in neighboring cells upon contact, and that c-Jun amino-terminal kinase (JNK) plays a pivotal role in mediating vesicle-induced CPS in recipient cells.

TL;DR: It is demonstrated that IL-15 influences the generation of memory CD8 T cells by first promoting their accumulation into mucosal tissues and second by sustaining expression of Bcl-6 and T-bet, which is largely dependent on mammalian target of rapamycin and its subsequent inactivation of FoxO1.