Jenna H. Newman

TL;DR: It is reported that unadjuvanted seasonal influenza vaccination via intratumoral, but not intramuscular, injection converts “cold” tumors to hot, generates systemic CD8+ T cell-mediated antitumor immunity, and sensitizes resistant tumors to checkpoint blockade, and proposes that antipathogen vaccines may be utilized for both infection prevention and repurposing as a cancer immunotherapy.

TL;DR: It is discovered that ONC201 exerts dose- and schedule-dependent effects on tumor progression and cell death signaling in vivo and that NK cell depletion inhibits OnC201 efficacy in vivo, including against TRAIL/ONC201-resistant Bax–/– tumors.

TL;DR: Weekly, oral ONC201 is well-tolerated and results in enhanced immunostimulatory activity that warrants further investigation.

TL;DR: The full contents of the supplement are available online at http://jitc.biomedcentral.com/articles/supplements/volume-4-supplement-1.

TL;DR: It is reported that acute influenza infection of the lung promotes distal melanoma growth in the dermis and leads to accelerated cancer-specific host death and an unexpected role for PD-1 blockade in cancer immunotherapy is suggested.