Josef Zamecnik

TL;DR: Three distinct molecular subgroups of ATRTs, associated with differences in demographics, tumor location, and type of SMARCB1 alterations, were identified, leading to the identification of subgroup-specific regulatory networks and potential therapeutic targets.

TL;DR: It is concluded that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies and revealing genetic alterations which may offer therapeutic opportunities.

TL;DR: TTF-1 should be added to a panel of antibodies used for assessing tumors of unknown origin because of its diagnostic utility and a significant decrease of SP-A immunoreactivity in poorly differentiated lung adenocarcinomas.

TL;DR: Children were more often drug-free; temporal lobe surgeries had the best seizure outcomes; and a longer duration of epilepsy was associated with reduced chance of favourable seizure outcomes and drug freedom.

TL;DR: The presence of tenascin in the ECS of the neoplasm correlates significantly with increased malignancy and poor clinical outcome of the disease, which makes its immunohistochemical detection useful as a marker of an aggressive biological behavior of the tumors.