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Christopher Dunham
Researcher at University of British Columbia
Publications - 67
Citations - 2344
Christopher Dunham is an academic researcher from University of British Columbia. The author has contributed to research in topics: Medulloblastoma & Medicine. The author has an hindex of 22, co-authored 62 publications receiving 1758 citations. Previous affiliations of Christopher Dunham include Washington University in St. Louis.
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Journal ArticleDOI
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
Ana Guerreiro Stucklin,Scott Ryall,Kohei Fukuoka,Michal Zapotocky,Michal Zapotocky,Alvaro Lassaletta,Christopher Li,Taylor Bridge,Byungjin Kim,Anthony Arnoldo,Paul E. Kowalski,Yvonne Zhong,Monique Johnson,Claire Li,Arun K. Ramani,Robert Siddaway,Liana Nobre,Pasqualino De Antonellis,Christopher Dunham,Sylvia Cheng,Daniel R. Boue,Daniel R. Boue,Jonathan L. Finlay,Scott L. Coven,Inmaculada de Prada,Marta Perez-Somarriba,Claudia C. Faria,Michael A. Grotzer,Elisabeth J. Rushing,David Sumerauer,Josef Zamecnik,Lenka Krskova,Miguel Garcia Ariza,Ofelia Cruz,Andres Morales La Madrid,Palma Solano,Keita Terashima,Yoshiko Nakano,Koichi Ichimura,Motoo Nagane,Hiroaki Sakamoto,Maria Joao Gil-da-Costa,Roberto Silva,Donna L. Johnston,Jean Michaud,Bev Wilson,Frank van Landeghem,Angelica Oviedo,Angelica Oviedo,P. Daniel McNeely,Bruce Crooks,Iris Fried,Nataliya Zhukova,Jordan R. Hansford,Jordan R. Hansford,Amulya NageswaraRao,Livia Garzia,Mary Shago,Michael Brudno,Meredith S. Irwin,Ute Bartels,Vijay Ramaswamy,Eric Bouffet,Michael D. Taylor,Uri Tabori,Cynthia Hawkins +65 more
TL;DR: It is concluded that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies and revealing genetic alterations which may offer therapeutic opportunities.
Journal ArticleDOI
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Jonathon Torchia,Brian Golbourn,Shengrui Feng,Shengrui Feng,King Ching Ho,Patrick Sin-Chan,Alexandre Vasiljevic,Joseph D. Norman,Paul Guilhamon,Livia Garzia,Natalia R. Agamez,Mei Lu,Tiffany Chan,Daniel Picard,Pasqualino De Antonellis,Dong Anh Khuong-Quang,Aline Cristiane Planello,Constanze Zeller,Dalia Barsyte-Lovejoy,Lucie Lafay-Cousin,Louis Letourneau,Mathieu Bourgey,Man Yu,Deena M.A. Gendoo,Misko Dzamba,Mark Barszczyk,Tiago Medina,Alexandra N. Riemenschneider,A. Sorana Morrissy,Young Shin Ra,Vijay Ramaswamy,Marc Remke,Christopher Dunham,Stephen Yip,Ho Keung Ng,Jian Qiang Lu,Vivek Mehta,Steffen Albrecht,José Pimentel,Jennifer A. Chan,Gino R. Somers,Claudia C. Faria,Lúcia Roque,Maryam Fouladi,Lindsey M. Hoffman,Andrew S. Moore,Yin Wang,Seung Ah Choi,Jordan R. Hansford,Daniel Catchpoole,Diane K. Birks,Nicholas K. Foreman,Doug Strother,Almos Klekner,László Bognár,Miklós Garami,Peter Hauser,Tibor Hortobágyi,Beverly Wilson,Juliette Hukin,Anne Sophie Carret,Timothy E. Van Meter,Eugene Hwang,Amar Gajjar,Shih Hwa Chiou,Hideo Nakamura,Helen Toledano,Iris Fried,Daniel W. Fults,Takafumi Wataya,Chris Fryer,David D. Eisenstat,Katrin Scheinemann,Adam Fleming,Donna L. Johnston,Jean Michaud,Shayna Zelcer,Robert Hammond,Samina Afzal,David A. Ramsay,Nongnuch Sirachainan,Suradej Hongeng,Noppadol Larbcharoensub,Richard Grundy,Rishi Lulla,Jason Fangusaro,Harriet Druker,Ute Bartels,Ronald Grant,David Malkin,C. Jane McGlade,Theodore Nicolaides,Tarik Tihan,Joanna J. Phillips,Jacek Majewski,Alexandre Montpetit,Guillaume Bourque,Gary D. Bader,Alyssa Reddy,G. Yancey Gillespie,Monika Warmuth-Metz,Stefan Rutkowski,Uri Tabori,Mathieu Lupien,Mathieu Lupien,Michael Brudno,Ulrich Schüller,Torsten Pietsch,Alexander R. Judkins,Cynthia Hawkins,Eric Bouffet,Seung-Ki Kim,Peter B. Dirks,Michael D. Taylor,Anat Erdreich-Epstein,Cheryl H. Arrowsmith,Daniel D. De Carvalho,Daniel D. De Carvalho,James T. Rutka,Nada Jabado,Annie Huang +120 more
TL;DR: It is discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and it is suggested that these are promising therapies for this highly lethal ATRT subtype.
Journal ArticleDOI
Significance of Necrosis in Grading of Oligodendroglial Neoplasms: A Clinicopathologic and Genetic Study of Newly Diagnosed High-Grade Gliomas
TL;DR: Stratification of AOA, but not of pure AO, into grades 3 and 4 on the basis of necrosis is prognostically justified and is more powerful than the current approach.
Journal ArticleDOI
Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.
Pooja Panwalkar,Jonathan Clark,Vijay Ramaswamy,Debra Hawes,Fusheng Yang,Christopher Dunham,Stephen Yip,Juliette Hukin,Yilun Sun,Matthew J. Schipper,Lukas Chavez,Ashley Margol,Melike Pekmezci,Chan Chung,Adam Banda,Jill Bayliss,Sarah J. Curry,Mariarita Santi,Fausto J. Rodriguez,Matija Snuderl,Matthias A. Karajannis,Amanda Saratsis,Amanda Saratsis,Craig Horbinski,Anne Sophie Carret,Beverly Wilson,Donna L. Johnston,Lucie Lafay-Cousin,Shayna Zelcer,David D. Eisenstat,M. Silva,Katrin Scheinemann,Katrin Scheinemann,Nada Jabado,P. Daniel McNeely,Marcel Kool,Stefan M. Pfister,Stefan M. Pfister,Michael D. Taylor,Cynthia Hawkins,Andrey Korshunov,Alexander R. Judkins,Sriram Venneti +42 more
TL;DR: In conclusion, immunohistochemical evaluation of H3K27me3 global reduction is an economic, easily available and readily adaptable method for defining high-risk EPN_PFA from low-risk posterior fossa EPN-PFB tumors to inform prognosis and to enable the design of future clinical trials.
Journal ArticleDOI
Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Vijay Ramaswamy,Thomas Hielscher,Stephen C. Mack,Stephen C. Mack,Alvaro Lassaletta,Tong Lin,Kristian W. Pajtler,David T.W. Jones,Betty Luu,Florence M.G. Cavalli,Kenneth Aldape,Marc Remke,Martin Mynarek,Stefan Rutkowski,Sridharan Gururangan,Roger E. McLendon,Eric S. Lipp,Christopher Dunham,Juliette Hukin,David D. Eisenstat,Dorcas Fulton,Frank van Landeghem,Mariarita Santi,Marie Lise C. van Veelen,Erwin G. Van Meir,Satoru Osuka,Xing Fan,Karin M. Muraszko,Daniela Pretti da Cunha Tirapelli,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Carlos Gilberto Carlotti,Ji Yeoun Lee,Amulya A. Nageswara Rao,Caterina Giannini,Claudia C. Faria,Sofia Nunes,Jaume Mora,Ronald L. Hamilton,Peter Hauser,Nada Jabado,Kevin Petrecca,Shin Jung,Luca Massimi,Massimo Zollo,Giuseppe Cinalli,László Bognár,Almos Klekner,Tibor Hortobágyi,Sarah Leary,Sarah Leary,Sarah Leary,Ralph P. Ermoian,Ralph P. Ermoian,Ralph P. Ermoian,James M. Olson,James M. Olson,James M. Olson,Jeffrey R. Leonard,Corrine Gardner,Wiesława Grajkowska,Lola B. Chambless,Jason E. Cain,Charles G. Eberhart,Sama Ahsan,Maura Massimino,Felice Giangaspero,Francesca R. Buttarelli,Roger J. Packer,Lyndsey Emery,William H. Yong,Horacio Soto,Linda M. Liau,Richard Everson,Andrew J. Grossbach,Tarek Shalaby,Michael A. Grotzer,Matthias A. Karajannis,David Zagzag,Helen Wheeler,Katja von Hoff,Marta M. Alonso,Teresa Tuñón,Ulrich Schüller,Karel Zitterbart,Jaroslav Sterba,Jennifer A. Chan,Miguel A. Guzman,Samer K. Elbabaa,Howard Colman,Girish Dhall,Paul G. Fisher,Maryam Fouladi,Amar Gajjar,Stewart Goldman,Eugene Hwang,Marcel Kool,Harshad Ladha,Elizabeth Vera-Bolanos,Khalida Wani,Frank S. Lieberman,Tom Mikkelsen,Antonio Omuro,Ian F. Pollack,Michael D. Prados,H. Ian Robins,Riccardo Soffietti,Jing Wu,Phillipe Metellus,Uri Tabori,Ute Bartels,Eric Bouffet,Cynthia Hawkins,James T. Rutka,Peter B. Dirks,Stefan M. Pfister,Stefan M. Pfister,Thomas E. Merchant,Mark R. Gilbert,Mark R. Gilbert,Terri S. Armstrong,Andrey Korshunov,David W. Ellison,Michael D. Taylor +123 more
TL;DR: The most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy.