J
Juan Ortín
Researcher at Spanish National Research Council
Publications - 103
Citations - 9936
Juan Ortín is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Virus & RNA. The author has an hindex of 53, co-authored 103 publications receiving 9551 citations. Previous affiliations of Juan Ortín include Carlos III Health Institute.
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Journal ArticleDOI
The multifunctional NS1 protein of influenza A viruses.
TL;DR: The basic biochemistry of NS1 is summarized, in particular its synthesis, structure, and intracellular localization, and the various roles NS1 has in regulating viral replication mechanisms, host innate/adaptive immune responses, and cellular signalling pathways are discussed.
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The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance — a review
Esteban Domingo,Encarnación Martínez-Salas,Francisco Sobrino,Juan Carlos de la Torre,Agustín Portela,Juan Ortín,Cecilio López-Galíndez,Pilar Pérez-Breña,Nieves Villanueva,Rafael Nájera,Scott VandePol,David A. Steinhauer,Nicholas J. Depolo,John J. Holland +13 more
TL;DR: Evidence that cloned (or uncloned) populations of most RNA viruses do not consist of a single genome species of defined sequence, but rather of heterogeneous mixtures of related genomes (quasispecies) is reviewed.
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The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.
Delphine Guilligay,Franck Tarendeau,Patricia Resa-Infante,Rocío Coloma,Thibaut Crépin,Peter Sehr,Joe Lewis,Rob W.H. Ruigrok,Juan Ortín,Darren J. Hart,Stephen Cusack +10 more
TL;DR: Binding and functional studies with point mutants confirm that the identified site is essential for cap binding in vitro and cap-dependent transcription in vivo by the trimeric polymerase complex, and will allow efficient structure-based design of new anti-influenza compounds inhibiting viral transcription.
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Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model
Taronna R. Maines,Li-Mei Chen,Yumiko Matsuoka,Hualan Chen,Thomas Rowe,Juan Ortín,Ana Falcón,Nguyen Tran Hien,Le Quynh Mai,Endang R. Sedyaningsih,Syahrial Harun,Terrence M. Tumpey,Ruben O. Donis,Nancy J. Cox,Kanta Subbarao,Jacqueline M. Katz +15 more
TL;DR: It is suggested that H5N1 viruses may require further adaptation to acquire this essential pandemic trait, and the complexity of the genetic basis of influenza virus transmissibility is highlighted.
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Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.
TL;DR: Inactivation of the NS1 gene, but not the NS2 gene, led to a substantial increase in the splicing efficiency, as shown by the relative accumulations of NS1 and NS2 mRNAs.