J
Judith A. Burger
Researcher at University of Amsterdam
Publications - 71
Citations - 3890
Judith A. Burger is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Neutralizing antibody. The author has an hindex of 18, co-authored 44 publications receiving 2525 citations.
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Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
Journal ArticleDOI
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils,Ronald Derking,Devin Sok,Devin Sok,Thomas J. Ketas,Judith A. Burger,Gabriel Ozorowski,Gabriel Ozorowski,Albert Cupo,Cassandra A. Simonich,Leslie Goo,Heather Arendt,Helen J. Kim,Helen J. Kim,Jeong Hyun Lee,Jeong Hyun Lee,Pavel Pugach,Melissa Williams,Gargi Debnath,Brian Moldt,Brian Moldt,Mariëlle J. van Breemen,Gözde Isik,Max Medina-Ramírez,Jaap Willem Back,Wayne C. Koff,Jean-Philippe Julien,Jean-Philippe Julien,Eva G. Rakasz,Michael S. Seaman,Michael S. Seaman,Miklos Guttman,Kelly K. Lee,Per Johan Klasse,Celia C. LaBranche,William R. Schief,Ian A. Wilson,Julie Overbaugh,Dennis R. Burton,Andrew B. Ward,Andrew B. Ward,David C. Montefiori,Hansi J. Dean,John P. Moore +45 more
TL;DR: A major goal of HIV-1 vaccine development is to identify immunogens capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating, neutralization-resistant (tier 2) viruses, and soluble, recombinant trimers based on the BG505 clade A and B41 clade B tier 2 viruses are engineered.
Journal ArticleDOI
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes
Steven W. de Taeye,Gabriel Ozorowski,Alba Torrents de la Peña,Miklos Guttman,Jean-Philippe Julien,Tom L.G.M. van den Kerkhof,Judith A. Burger,Laura K. Pritchard,Pavel Pugach,Anila Yasmeen,Jordan C. Crampton,Joyce K. Hu,Ilja Bontjer,Jonathan L. Torres,Heather Arendt,Joanne DeStefano,Wayne C. Koff,Hanneke Schuitemaker,Dirk Eggink,Ben Berkhout,Hansi J. Dean,Celia C. LaBranche,Shane Crotty,Max Crispin,David C. Montefiori,Per Johan Klasse,Kelly K. Lee,John P. Moore,Ian A. Wilson,Andrew B. Ward,Rogier W. Sanders,Rogier W. Sanders +31 more
TL;DR: Stabilized, closed trimers might be useful components of vaccines aimed at inducing bNAbs, and induced similar autologous Tier-1B or Tier-2 NAb titers to those elicited by the corresponding wild-type trimers but lower levels of V3-directed Tier- 1A NAbs in rabbits.
Journal ArticleDOI
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity
Kwinten Sliepen,Gabriel Ozorowski,Judith A. Burger,Thijs van Montfort,Melissa Stunnenberg,Celia C. LaBranche,David C. Montefiori,John P. Moore,Andrew B. Ward,Rogier W. Sanders,Rogier W. Sanders +10 more
TL;DR: In this paper, the authors describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664).
Journal ArticleDOI
Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.
Alba Torrents de la Peña,Jean-Philippe Julien,Steven W. de Taeye,Fernando Garces,Miklos Guttman,Gabriel Ozorowski,Laura K. Pritchard,Anna-Janina Behrens,Eden P. Go,Judith A. Burger,Edith E. Schermer,Kwinten Sliepen,Thomas J. Ketas,Pavel Pugach,Anila Yasmeen,Christopher A. Cottrell,Jonathan L. Torres,Charlotte D. Vavourakis,Marit J. van Gils,Celia C. LaBranche,David C. Montefiori,Heather Desaire,Max Crispin,Per Johan Klasse,Kelly K. Lee,John P. Moore,Andrew B. Ward,Ian A. Wilson,Rogier W. Sanders,Rogier W. Sanders +29 more
TL;DR: How the introduction of new disulfide bonds between the glycoprotein (gp)120 and gp41 subunits of SOSIP trimers of the BG505 and other genotypes improves their stability and antigenicity, reduces their conformational flexibility, and helps maintain them in the unliganded conformation is described.