J
Jelle van Schooten
Researcher at University of Amsterdam
Publications - 19
Citations - 1740
Jelle van Schooten is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Epitope & Neutralizing antibody. The author has an hindex of 9, co-authored 14 publications receiving 1043 citations.
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Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
Journal ArticleDOI
Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.
Hejun Liu,Nicholas C. Wu,Meng Yuan,Sandhya Bangaru,Jonathan L. Torres,Tom G. Caniels,Jelle van Schooten,Xueyong Zhu,Chang-Chun D Lee,Philip J. M. Brouwer,Marit J. van Gils,Rogier W. Sanders,Rogier W. Sanders,Andrew B. Ward,Ian A. Wilson +14 more
TL;DR: The crystal structure of the COVA1-16 antibody fragment with the SARS-CoV-2 receptor-binding domain (RBD) and negative-stain electron microscopy reconstructions with the spike glycoprotein trimer are determined to elucidate the structural basis of its cross-reactivity.
Posted ContentDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: Mapping studies revealed that the SARS-CoV-2 spike protein contained multiple distinct antigenic sites, including several receptor-binding domain (RBD) epitopes as well as previously undefined non-RBD epitopes, which provide guidance for vaccine design and are promising candidates for treatment and prevention of COVID-19.
Journal ArticleDOI
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection.
Philip J. M. Brouwer,Mitch Brinkkemper,Pauline Maisonnasse,Nathalie Dereuddre-Bosquet,Marloes Grobben,Mathieu Claireaux,Marlon de Gast,Romain Marlin,Virginie Chesnais,Ségolène Diry,Joel D. Allen,Yasunori Watanabe,Yasunori Watanabe,Julia M. Giezen,Gius Kerster,Hannah L. Turner,Karlijn van der Straten,Cynthia A. van der Linden,Yoann Aldon,Thibaut Naninck,Ilja Bontjer,Judith A. Burger,Meliawati Poniman,Anna Z Mykytyn,Nisreen M.A. Okba,Edith E. Schermer,Mariëlle J. van Breemen,Rashmi Ravichandran,Tom G. Caniels,Jelle van Schooten,Nidhal Kahlaoui,Vanessa Contreras,Julien Lemaitre,Catherine Chapon,Raphael Ho Tsong Fang,Julien Villaudy,Kwinten Sliepen,Yme U. van der Velden,Bart L. Haagmans,Godelieve J. de Bree,Eric Ginoux,Andrew B. Ward,Max Crispin,Neil P. King,Sylvie van der Werf,Sylvie van der Werf,Marit J. van Gils,Roger Le Grand,Rogier W. Sanders +48 more
TL;DR: In this paper, a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein was proposed to curtail the severe acute respiratory syndrome coronavirus 2 pandemic.
Posted ContentDOI
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Hejun Liu,Nicholas C. Wu,Meng Yuan,Sandhya Bangaru,Jonathan L. Torres,Tom G. Caniels,Jelle van Schooten,Xueyong Zhu,Chang-Chun D Lee,Philip J. M. Brouwer,Marit J. van Gils,Rogier W. Sanders,Rogier W. Sanders,Andrew B. Ward,Ian A. Wilson +14 more
TL;DR: A crystal structure of COVA1-16 Fab with the SARS-CoV-2 RBD, and a negative-stain EM reconstruction with the spike glycoprotein trimer are determined, to elucidate the structural basis of its cross-reactivity and provide a blueprint for development of more universal Sars-like coronavirus vaccines and therapies.