M
Marit J. van Gils
Researcher at University of Amsterdam
Publications - 117
Citations - 5929
Marit J. van Gils is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 28, co-authored 55 publications receiving 4482 citations. Previous affiliations of Marit J. van Gils include Cornell University & International AIDS Vaccine Initiative.
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Journal ArticleDOI
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Rogier W. Sanders,Rogier W. Sanders,Ronald Derking,Albert Cupo,Jean-Philippe Julien,Anila Yasmeen,Natalia de Val,Helen J. Kim,Claudia Blattner,Alba Torrents de la Peña,Jacob Korzun,Michael Golabek,Kevin de los Reyes,Thomas J. Ketas,Marit J. van Gils,C. Richter King,Ian A. Wilson,Andrew B. Ward,Per Johan Klasse,John P. Moore +19 more
TL;DR: The design and properties of soluble, cleaved SOSIP trimers based on the subtype A transmitted/founder strain, BG505, are described, which are highly stable and homogenous and closely resemble native virus spikes when visualized by negative stain electron microscopy (EM).
Journal ArticleDOI
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface
Jinghe Huang,Byong H. Kang,Marie Pancera,Jeong Hyun Lee,Tommy Tong,Yu Feng,Hiromi Imamichi,Ivelin S. Georgiev,Gwo-Yu Chuang,Aliaksandr Druz,Nicole A. Doria-Rose,Leo B. Laub,Kwinten Sliepen,Marit J. van Gils,Alba Torrents de la Peña,Ronald Derking,Per Johan Klasse,Stephen A. Migueles,Robert T. Bailer,Munir Alam,Pavel Pugach,Barton F. Haynes,Richard T. Wyatt,Rogier W. Sanders,James M. Binley,Andrew B. Ward,John R. Mascola,Peter D. Kwong,Mark Connors +28 more
TL;DR: A broad and extremely potent HIV-specific monoclonal antibody, termed 35O22, which binds a novel HIV-1 envelope glycoprotein (Env) epitope, which represents a novel site of vulnerability on HIV Env, which serum analysis indicates to be commonly elicited by natural infection.
Journal ArticleDOI
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
Emilia Falkowska,Khoa Le,Khoa Le,Alejandra Ramos,Alejandra Ramos,Katie J. Doores,Katie J. Doores,Katie J. Doores,Jeong Hyun Lee,Jeong Hyun Lee,Claudia Blattner,Claudia Blattner,Alejandro Ramirez,Ronald Derking,Marit J. van Gils,Chi-Hui Liang,Chi-Hui Liang,Ryan McBride,Benjamin von Bredow,Sachin S. Shivatare,Chung-Yi Wu,Po-Ying Chan-Hui,Yan Liu,Ten Feizi,Michael B. Zwick,Wayne C. Koff,Michael S. Seaman,Kristine M. Swiderek,John P. Moore,David T. Evans,James C. Paulson,Chi-Huey Wong,Andrew B. Ward,Andrew B. Ward,Ian A. Wilson,Rogier W. Sanders,Pascal Poignard,Pascal Poignard,Dennis R. Burton +38 more
TL;DR: The availability of this set of antibodies expands the number of vaccine targets on HIV and provides reagents to characterize the native envelope spike, an important property given increasing evidence that cleavage is required for vaccine candidates that seek to mimic the functional HIV envelope spike.
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Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
Claudia Blattner,Jeong Hyun Lee,Kwinten Sliepen,Ronald Derking,Emilia Falkowska,Alba Torrents de la Peña,Albert Cupo,Jean-Philippe Julien,Marit J. van Gils,Peter Lee,Wenjie Peng,James C. Paulson,Pascal Poignard,Dennis R. Burton,John P. Moore,Rogier W. Sanders,Rogier W. Sanders,Ian A. Wilson,Andrew B. Ward +18 more
TL;DR: This work defines and structurally characterize a unique epitope on Env that is recognized by a recently discovered family of human monoclonal antibodies (PGT151-PGT158), and compares the structural and functional properties of membrane-extracted Env trimers from several clades with those of the soluble, cleaved SOSIP gp140 trimer.
Journal ArticleDOI
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.
Devin Sok,Marit J. van Gils,Matthias Pauthner,Jean-Philippe Julien,Karen L. Saye-Francisco,Jessica Hsueh,Bryan Briney,Jeong Hyun Lee,Khoa Le,Peter Lee,Yuanzi Hua,Michael S. Seaman,John P. Moore,Andrew B. Ward,Ian A. Wilson,Rogier W. Sanders,Rogier W. Sanders,Dennis R. Burton +17 more
TL;DR: The use of a recombinant HIV envelope trimer as an affinity reagent to isolate quaternary-dependent bnAbs from the peripheral blood mononuclear cells of a chronically infected donor highlights the utility of BG505 SOSIP and reveals a mosaic of antibody responses against the trimer apex within a clonal family.