T
Tom G. Caniels
Researcher at University of Amsterdam
Publications - 37
Citations - 2722
Tom G. Caniels is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 10, co-authored 22 publications receiving 1304 citations. Previous affiliations of Tom G. Caniels include Utrecht University.
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Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
Journal ArticleDOI
SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees.
Daryl Geers,Marc C. Shamier,Susanne Bogers,Gerco den Hartog,Lennert Gommers,Nella N Nieuwkoop,Katharina S. Schmitz,Laurine C Rijsbergen,Jolieke A T van Osch,Emma Dijkhuizen,Gaby Smits,Anouskha D. Comvalius,Djenolan van Mourik,Tom G. Caniels,Marit J. van Gils,Rogier W. Sanders,Bas B. Oude Munnink,Richard Molenkamp,Herbert de Jager,Bart L. Haagmans,Rik L. de Swart,Marion Koopmans,Robert S. van Binnendijk,Rory D. de Vries,Corine H. GeurtsvanKessel +24 more
TL;DR: In this article, the authors studied humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.7 and B.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinated health care workers.
Journal ArticleDOI
Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity.
Hejun Liu,Nicholas C. Wu,Meng Yuan,Sandhya Bangaru,Jonathan L. Torres,Tom G. Caniels,Jelle van Schooten,Xueyong Zhu,Chang-Chun D Lee,Philip J. M. Brouwer,Marit J. van Gils,Rogier W. Sanders,Rogier W. Sanders,Andrew B. Ward,Ian A. Wilson +14 more
TL;DR: The crystal structure of the COVA1-16 antibody fragment with the SARS-CoV-2 receptor-binding domain (RBD) and negative-stain electron microscopy reconstructions with the spike glycoprotein trimer are determined to elucidate the structural basis of its cross-reactivity.
Journal ArticleDOI
An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain.
Nicholas C. Wu,Meng Yuan,Hejun Liu,Chang-Chun D Lee,Xueyong Zhu,Sandhya Bangaru,Jonathan L. Torres,Tom G. Caniels,Philip J. M. Brouwer,Marit J. van Gils,Rogier W. Sanders,Rogier W. Sanders,Andrew B. Ward,Ian A. Wilson +13 more
TL;DR: Crystal structures of two IGHV3-53 neutralizing antibodies here demonstrate that a longer CDR H3 can be accommodated in a different binding mode (mode B) for SARS-CoV-2 RBD recognition and virus neutralization.
Journal ArticleDOI
High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages.
Willianne Hoepel,Hung-Jen Chen,Chiara Elisabeth Geyer,Sona Allahverdiyeva,Xue D. Manz,Steven W. de Taeye,Jurjan Aman,Lynn Mes,Maurice Steenhuis,Guillermo R. Griffith,Peter I. Bonta,Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Korneliusz Golebski,René E. Jonkers,Mads Delbo Larsen,Federica Linty,Jan Nouta,Cindy P. A. A. van Roomen,Frank E.H.P. van Baarle,Cornelis M. van Drunen,Gertjan Wolbink,Alexander P.J. Vlaar,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Lisa Willemsen,Annette E. Neele,Diederik van de Beek,Theo Rispens,Manfred Wuhrer,Harm Jan Bogaard,Marit J. van Gils,Gestur Vidarsson,Menno P.J. de Winther,Jeroen den Dunnen +36 more
TL;DR: In this paper, the authors show that early-phase severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) spike protein-specific immunoglobulin G (IgG) in serum of critically ill COVID-19 patients induces excessive inflammatory responses by human alveolar macrophages.