Sang Hun Lee

TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.

TL;DR: The mechanism of autophagy under stressful conditions and its roles in tumor suppression and promotion in cancer and in cancer stem-cells are summarized and how Autophagy is a promising potential therapeutic target in cancer treatment is discussed.

TL;DR: The role of VEGF in promoting tumor angiogenesis and the occurrence of human cancers has led to the rational design and development of agents that selectively target this pathway, and these anti-VEGF/VEGF receptor agents show therapeutic potential by inhibition of angiogenic and tumor growth in preclinical models.

TL;DR: Taken together, HSPs have multiple clinical usages as biomarkers for cancer diagnosis and prognosis as well as the potential therapeutic targets for anti-cancer treatment.

TL;DR: It is indicated that hypoxic preconditioning promotes survival, proliferation, and angiogenic cytokine secretion of MSCs via the HIF-1α-GRP78-Akt signal pathway, suggesting that hypoxia-preconditioned MSC’s might provide a therapeutic strategy for MSC-based therapies and that GRP78 represents a potential target for the development of functional M SCs.