J
Jussi Taipale
Researcher at University of Helsinki
Publications - 171
Citations - 31981
Jussi Taipale is an academic researcher from University of Helsinki. The author has contributed to research in topics: Gene & Transcription factor. The author has an hindex of 64, co-authored 164 publications receiving 27737 citations. Previous affiliations of Jussi Taipale include University of Washington & Ludwig Institute for Cancer Research.
Papers
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Journal ArticleDOI
Structural perspective of cooperative transcription factor binding.
TL;DR: An overview of the structural basis of the different mechanisms by which TFs can cooperate is presented, focusing on insight from recent functional studies and structural analyses of specific TF-TF-DNA complexes.
Journal ArticleDOI
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function
TL;DR: Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling and subsequent transcription.
Book ChapterDOI
Vascular Endothelial Growth Factor Receptor-3
TL;DR: Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelialcell growth factor receptors.
Journal ArticleDOI
Identification and characterization of a new latent transforming growth factor-beta-binding protein, LTBP-4
TL;DR: LTBP-4 is a new member of the growing LTBP-fibrillin family of proteins and offers an alternative means for the secretion and targeted matrix deposition of TGF-βs or related proteins.
Journal ArticleDOI
Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.
Mikko P. Turunen,Jason M. Spaeth,Salla Keskitalo,Min Ju Park,Teemu Kivioja,Alison D. Clark,Netta Mäkinen,Fangjian Gao,Kimmo Palin,Helka Nurkkala,Anna Vähärautio,Mervi Aavikko,Kati Kämpjärvi,Pia Vahteristo,Chongwoo A. Kim,Lauri A. Aaltonen,Markku Varjosalo,Jussi Taipale,Jussi Taipale,Thomas G. Boyer +19 more
TL;DR: Findings indicate that uterine leiomyoma-linked mutations in MED12 uncouple Cyclin C-CDK8/19 from core Mediator and further identify the MED12/Cyclin C interface as a prospective therapeutic target in CDK8-driven cancers.