J
Jussi Taipale
Researcher at University of Helsinki
Publications - 171
Citations - 31981
Jussi Taipale is an academic researcher from University of Helsinki. The author has contributed to research in topics: Gene & Transcription factor. The author has an hindex of 64, co-authored 164 publications receiving 27737 citations. Previous affiliations of Jussi Taipale include University of Washington & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
High-throughput assay for determining specificity and affinity of protein-DNA binding interactions.
Outi Hallikas,Jussi Taipale +1 more
TL;DR: The detailed protocol for determining sequence specificities of DNA-binding proteins using this microwell-based assay is described, suitable for high-throughput screening to identify proteins or small molecules that modulate protein-DNA binding interactions.
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Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth
Kashyap Dave,Inderpreet Sur,Jian Yan,Jilin Zhang,Eevi Kaasinen,Fan Zhong,Leander Blaas,Xiaoze Li,Shabnam Kharazi,Charlotte Gustafsson,Ayla De Paepe,Robert Månsson,Jussi Taipale,Jussi Taipale +13 more
TL;DR: It is shown that a 538 kb deletion of the entire MYC upstream super-enhancer region in mice results in 50% to 80% decrease in Myc expression in multiple tissues, and indicates that targeting the activity of this element is a promising strategy of cancer chemoprevention and therapy.
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FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase–FGFR4 complex
Nami Sugiyama,Markku Varjosalo,Pipsa Meller,Jouko Lohi,Kui Ming Chan,Zhongjun Zhou,Kari Alitalo,Jussi Taipale,Jussi Taipale,Jorma Keski-Oja,Kaisa Lehti +10 more
TL;DR: The results provide a mechanistic basis for FGFR4-R388 function in cancer invasion and identify kinases that significantly enhance MT1-MMP activity in tumor cells.
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Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Nami Sugiyama,Markku Varjosalo,Pipsa Meller,Jouko Lohi,Marko Hyytiäinen,Sami Kilpinen,Olli Kallioniemi,Signe Ingvarsen,Lars H. Engelholm,Jussi Taipale,Kari Alitalo,Jorma Keski-Oja,Kaisa Lehti +12 more
TL;DR: A novel mechanism of tumor progression by matrix degradation involving epithelial-to-mesenchymal transition in response to membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) induction at the edge of tumors expressing the FGFR4-R388 risk variant is described.
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Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer
Giulia Orlando,Philip J. Law,Alex J. Cornish,Sara E. Dobbins,Daniel Chubb,Peter Broderick,Kevin Litchfield,Fadi Hariri,Tomi Pastinen,Tomi Pastinen,Cameron S. Osborne,Jussi Taipale,Jussi Taipale,Jussi Taipale,Richard S. Houlston +14 more
TL;DR: Promoter capture Hi-C in colorectal cancer cells integrated with cancer genome and expression data identifies a noncoding, cis-regulatory element that is recurrently mutated in cancer, affecting ETV1 expression, cell viability and patient survival.