J
Jussi Taipale
Researcher at University of Helsinki
Publications - 171
Citations - 31981
Jussi Taipale is an academic researcher from University of Helsinki. The author has contributed to research in topics: Gene & Transcription factor. The author has an hindex of 64, co-authored 164 publications receiving 27737 citations. Previous affiliations of Jussi Taipale include University of Washington & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein
TL;DR: The results suggest that the latent form of TGF-beta 1 associates with the extracellular matrix via LTBP, and that the release of latent TGF -beta 1 from the matrix is a consequence of proteolytic cleavage(s) of LTBP.
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Minimizing the risk of reporting false positives in large-scale RNAi screens
C Echeverri,Philip A. Beachy,Buzz Baum,Michael Boutros,Frank Buchholz,Sumit K. Chanda,Julian Downward,Jan Ellenberg,Andrew G. Fraser,Nir Hacohen,Nir Hacohen,William C. Hahn,William C. Hahn,Aimee L. Jackson,Amy A. Kiger,Peter S. Linsley,Lawrence G. Lum,Yong Ma,Bernard Mathey-Prevot,David E. Root,David M. Sabatini,Jussi Taipale,Norbert Perrimon,Norbert Perrimon,René Bernards +24 more
TL;DR: This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens.
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Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities
Arttu Jolma,Teemu Kivioja,Jarkko Toivonen,Lu Cheng,Gong-Hong Wei,Martin Enge,Mikko Taipale,Juan M. Vaquerizas,Jian Yan,Mikko J. Sillanpää,Martin Bonke,Kimmo Palin,Shaheynoor Talukder,Timothy P. Hughes,Nicholas M. Luscombe,Esko Ukkonen,Jussi Taipale +16 more
TL;DR: A high-throughput method for analyzing transcription factor binding specificity that is based on systematic evolution of ligands by exponential enrichment (SELEX) and massively parallel sequencing is described and reveals unexpected dimeric modes of binding for several factors that were thought to preferentially bind DNA as monomers.
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DNA-dependent formation of transcription factor pairs alters their binding specificity
Arttu Jolma,Yimeng Yin,Kazuhiro R. Nitta,Kashyap Dave,Alexander Popov,Minna Taipale,Martin Enge,Teemu Kivioja,Ekaterina Morgunova,Jussi Taipale,Jussi Taipale +10 more
TL;DR: The results indicate that the DNA molecule commonly plays an active role in cooperative interactions that define the gene regulatory lexicon.
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Human mast cell chymase and leukocyte elastase release latent transforming growth factor-beta 1 from the extracellular matrix of cultured human epithelial and endothelial cells.
TL;DR: The release of TGF-β from the matrix by leukocyte and mast cell enzymes may contribute to the accumulation of connective tissue in inflammation.