J
Jussi Taipale
Researcher at University of Helsinki
Publications - 171
Citations - 31981
Jussi Taipale is an academic researcher from University of Helsinki. The author has contributed to research in topics: Gene & Transcription factor. The author has an hindex of 64, co-authored 164 publications receiving 27737 citations. Previous affiliations of Jussi Taipale include University of Washington & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Hepatocyte Growth Factor Releases Epithelial and Endothelial Cells from Growth Arrest Induced by Transforming Growth Factor-β1
Jussi Taipale,Jorma Keski-Oja +1 more
TL;DR: The results imply that proteolytic activity of epithelial and endothelial cells directs their responses to signals from mesenchymal-type extracellular matrices, and that during development, matrix-bound growth and invasion promoting and suppressing factors are activated in a coordinated manner.
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The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression
Ning Qing Liu,Menno ter Huurne,Luan Nguyen,Tianran Peng,Shuang-Yin Wang,James B. Studd,Onkar Joshi,Halit Ongen,Jesper B. Bramsen,Jian Yan,Jian Yan,Claus L. Andersen,Jussi Taipale,Emmanouil T. Dermitzakis,Richard S. Houlston,Nina C. Hubner,Hendrik G. Stunnenberg +16 more
TL;DR: A large-scale PWAS study is performed to comprehensively characterize TF-binding landscape that is associated with CRC, which identifies 731 allele-specific TF binding at 116 CRC risk loci.
Journal ArticleDOI
Identification of Candidate Oncogenes in Human Colorectal Cancers With Microsatellite Instability
Alexandra E. Gylfe,Johanna Kondelin,Mikko P. Turunen,Heikki Ristolainen,Riku Katainen,Esa Pitkänen,Eevi Kaasinen,Ville Rantanen,Tomas Tanskanen,Markku Varjosalo,Heli J. Lehtonen,Kimmo Palin,Minna Taipale,Jussi Taipale,Laura Renkonen–Sinisalo,Heikki Järvinen,Jan Böhm,Jukka-Pekka Mecklin,Ari Ristimäki,Outi Kilpivaara,Sari Tuupanen,Auli Karhu,Pia Vahteristo,Lauri A. Aaltonen +23 more
TL;DR: The exomes of 25 colorectal tumors and respective healthy colon tissue were sequenced to detect new oncogenes and ZBTB2, RANBP2, and PSRC1 found to contain hot spot mutations in the validation set, which might be used to develop personalized tumor profiling and therapy.
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Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer.
David Jarvis,Jonathan S. Mitchell,Philip J. Law,Kimmo Palin,Sari Tuupanen,Alexandra E. Gylfe,Ulrika A. Hänninen,Tatiana Cajuso,Tomas Tanskanen,Johanna Kondelin,Eevi Kaasinen,Antti-Pekka Sarin,Jaakko Kaprio,Jaakko Kaprio,Johan G. Eriksson,Johan G. Eriksson,Harri Rissanen,Paul Knekt,Eero Pukkala,Pekka Jousilahti,Veikko Salomaa,Samuli Ripatti,Aarno Palotie,Heikki Järvinen,Laura Renkonen-Sinisalo,Anna Lepistö,Jan Böhm,Jukka Pekka Meklin,Nada Al-Tassan,Claire Palles,Lynn Martin,Ella Barclay,Susan M. Farrington,Maria Timofeeva,Brian F. Meyer,Salma M. Wakil,Harry Campbell,Christopher Smith,Shelley Idziaszczyk,Tim Maughan,Richard Kaplan,Rachel Kerr,David J. Kerr,Daniel D. Buchanan,Aung Ko Win,John L. Hopper,Mark A. Jenkins,Noralane M. Lindor,Polly A. Newcomb,S. Gallinger,David V. Conti,Fred Schumacher,Graham Casey,Jussi Taipale,Jussi Taipale,Lauri A. Aaltonen,Jeremy Peter Cheadle,Malcolm G. Dunlop,Ian Tomlinson,Richard S. Houlston +59 more
TL;DR: Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer as discussed by the authors, showing that adiposity is associated with increased risk of colortal cancer.
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CRISPR/Cas9 screening using unique molecular identifiers
Bernhard Schmierer,Sandeep Kumar Botla,Jilin Zhang,Mikko P. Turunen,Teemu Kivioja,Jussi Taipale,Jussi Taipale +6 more
TL;DR: Random Sequence Labels (RSLs) are incorporated into the guide library, which act as unique molecular identifiers (UMIs) to allow massively parallel lineage tracing and lineage dropout screening.