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Kai Blin

Researcher at Technical University of Denmark

Publications -  50
Citations -  11833

Kai Blin is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Gene cluster & CRISPR. The author has an hindex of 24, co-authored 45 publications receiving 8460 citations. Previous affiliations of Kai Blin include Novo Nordisk Foundation & University of Groningen.

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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

TL;DR: AntiSMASH 5 adds detection rules for clusters encoding the biosynthesis of acyl-amino acids, β-lactones, fungal RiPPs, RaS-Ri PPs, polybrominated diphenyl ethers, C-nucleosides, PPY-like ketones and lipolanthines and provides more detailed predictions for type II polyketide synthase-encoding gene clusters.
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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

TL;DR: This work presents the first comprehensive pipeline capable of identifying biosynthetic loci covering the whole range of known secondary metabolite compound classes, and integrates or cross-links all previously available secondary-metabolite specific gene analysis methods in one interactive view.
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antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification.

TL;DR: The thoroughly updated antiSMASH version 4 is presented, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, and several usability features have been updated and improved.
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antiSMASH 6.0: improving cluster detection and comparison capabilities.

TL;DR: antiSMASH as mentioned in this paper is the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in bacteria and fungi, and it is updated version 6 of antiSMASH.