Xiaowen Lu

TL;DR: The thoroughly updated antiSMASH version 4 is presented, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, and several usability features have been updated and improved.

TL;DR: Findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP, as well as two new MAP loci associated with both of these traits.

TL;DR: It is demonstrated that SCN10A, a candidate gene at the most significantly associated locus in this study, is expressed in the mouse ventricular conduction system, and treatment with a selective SCN 10A blocker prolongs QRS duration.

TL;DR: By indexing the Pseudomonas specialized metabolome, this work reports the molecular-networking-based discovery of four molecules and their evolutionary relationships: a poaeamide analogue and a molecular subfamily of cyclic lipopeptides, bananamides 1, 2 and 3.

TL;DR: This work demonstrates how complex innovations can evolve through series of adaptive steps without the need to invoke non-adaptive processes.