Karla E. Hirokawa

TL;DR: In this paper, the authors systematically examined complete single-neuron morphologies on a brain-wide scale, established a pipeline encompassing sparse labeling, whole-brain imaging, reconstruction, registration and analysis, and identified 11 major projection neuron types with distinct morphological features and corresponding transcriptomic identities.

TL;DR: It is found that the mouse DMN consists of preferentially interconnected cortical regions, and two L5 projection types differentiated by in- or out-DMN targets, laminar position, and gene expression are identified.

TL;DR: This work derives a comprehensive cell type-based description of one brain structure - the primary motor cortex upper limb area (MOp-ul) of the mouse - and provides a roadmap towards a cellular resolution description of mammalian brain architecture.

TL;DR: In this article, the authors derived a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul), using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools.

TL;DR: How whole brain imaging of amyloid pathology in mice reveals the extent to which a given model recapitulates the regional Aβ deposition patterns described in AD is shown is shown.