C
Cindy T. J. van Velthoven
Researcher at Allen Institute for Brain Science
Publications - 17
Citations - 1092
Cindy T. J. van Velthoven is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Gene isoform & Parvocellular cell. The author has an hindex of 8, co-authored 17 publications receiving 298 citations.
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Journal ArticleDOI
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Zizhen Yao,Cindy T. J. van Velthoven,Thuc Nghi Nguyen,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Megan Chiang,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,Nathan W. Gouwens,James Gray,Lucas T. Graybuck,Michael Hawrylycz,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Changkyu Lee,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +38 more
TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.
Posted ContentDOI
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Zizhen Yao,Thuc Nghi Nguyen,Cindy T. J. van Velthoven,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,James Gray,Lucas T. Graybuck,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +34 more
TL;DR: This study establishes a molecular architecture of the mammalian isocortex and hippocampal formation for the first time, and begins to shed light on its underlying relationship with the development, evolution, connectivity and function of these two brain structures.
Journal ArticleDOI
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex.
Zizhen Yao,Hanqing Liu,Fangming Xie,Stephan Fischer,Ricky S. Adkins,Andrew Aldridge,Seth A. Ament,Anna Bartlett,M. Margarita Behrens,Koen Van den Berge,Koen Van den Berge,Darren Bertagnolli,Hector Roux de Bézieux,Tommaso Biancalani,A. Sina Booeshaghi,Héctor Corrada Bravo,Tamara Casper,Carlo Colantuoni,Carlo Colantuoni,Jonathan Crabtree,Heather Huot Creasy,Kirsten Crichton,Megan Crow,Nick Dee,Elizabeth L. Dougherty,Wayne I. Doyle,Sandrine Dudoit,Rongxin Fang,Victor Felix,Olivia Fong,Michelle G. Giglio,Jeff Goldy,Michael Hawrylycz,Brian R. Herb,Ronna Hertzano,Xiaomeng Hou,Qiwen Hu,Jayaram Kancherla,Matthew Kroll,Kanan Lathia,Yang Eric Li,Jacinta Lucero,Chongyuan Luo,Chongyuan Luo,Anup Mahurkar,Delissa McMillen,Naeem Nadaf,Joseph R. Nery,Thuc Nghi Nguyen,Sheng-Yong Niu,Vasilis Ntranos,Joshua Orvis,Julia K. Osteen,Thanh Pham,Antonio Pinto-Duarte,Olivier Poirion,Sebastian Preissl,Elizabeth Purdom,Christine Rimorin,Davide Risso,Angeline Rivkin,Kimberly A. Smith,Kelly Street,Josef Sulc,Valentine Svensson,Michael Tieu,Amy Torkelson,Herman Tung,Eeshit Dhaval Vaishnav,Charles R. Vanderburg,Cindy T. J. van Velthoven,Xinxin Wang,Xinxin Wang,Owen White,Z. Josh Huang,Peter V. Kharchenko,Lior Pachter,John Ngai,Aviv Regev,Aviv Regev,Bosiljka Tasic,Joshua D. Welch,Jesse Gillis,Evan Z. Macosko,Bing Ren,Bing Ren,Joseph R. Ecker,Hongkui Zeng,Eran A. Mukamel +88 more
TL;DR: In this paper, a reference atlas of diverse neuronal and non-neuronal cell types in the mouse primary motor cortex is presented, including a population of excitatory neurons that resemble pyramidal cells in layer 4.
Journal ArticleDOI
Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network
Jennifer D. Whitesell,Adam Liska,Ludovico Coletta,Ludovico Coletta,Karla E. Hirokawa,Phillip Bohn,Ali Williford,Peter A. Groblewski,Nile Graddis,Leonard Kuan,Joseph E. Knox,Anh Ho,Wayne Wakeman,Philip R. Nicovich,Thuc Nghi Nguyen,Cindy T. J. van Velthoven,Emma Garren,Olivia Fong,Maitham Naeemi,Alex M. Henry,Nick Dee,Kimberly A. Smith,Boaz P. Levi,David Feng,Lydia Ng,Bosiljka Tasic,Hongkui Zeng,Stefan Mihalas,Alessandro Gozzi,Julie A. Harris +29 more
TL;DR: It is found that the mouse DMN consists of preferentially interconnected cortical regions, and two L5 projection types differentiated by in- or out-DMN targets, laminar position, and gene expression are identified.
Journal ArticleDOI
Enhancer viruses for combinatorial cell-subclass-specific labeling
Lucas T. Graybuck,Tanya L. Daigle,Adriana E. Sedeno-Cortes,Miranda Walker,Brian E. Kalmbach,Brian E. Kalmbach,Garreck H. Lenz,Elyse Morin,Thuc Nghi Nguyen,Emma Garren,Jacqueline L. Bendrick,Tae Kyung Kim,Thomas Zhou,Marty Mortrud,Shenqin Yao,La'Akea Siverts,Rachael Larsen,Bryan B. Gore,Eric R. Szelenyi,Cameron Trader,Pooja Balaram,Cindy T. J. van Velthoven,Megan Chiang,John K. Mich,Nick Dee,Jeff Goldy,Ali Cetin,Ali Cetin,Kimberly A. Smith,Sharon W. Way,Luke Esposito,Zizhen Yao,Viviana Gradinaru,Susan M. Sunkin,Ed S. Lein,Ed S. Lein,Boaz P. Levi,Jonathan T. Ting,Jonathan T. Ting,Hongkui Zeng,Bosiljka Tasic +40 more
TL;DR: In this paper, the authors used chromatin accessibility data from individual cells and identified enhancers specific for cell subclasses and types to facilitate access to specific neural populations in mouse cortex.