Stephan Fischer

TL;DR: The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals using high-throughput transcriptomic and epigenomic profiling of more than 450k single nuclei in humans, marmoset monkeys and mice as mentioned in this paper.

TL;DR: This study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps, and establishes a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.

TL;DR: BARseq is introduced, a multiplexed method based on RNA barcoding for mapping projections of thousands of spatially resolved neurons in a single brain and relating those projections to other properties such as gene or Cre expression that can potentially uncover the organizing principles underlying the structure and formation of neural circuits.

TL;DR: In this paper, a reference atlas of diverse neuronal and non-neuronal cell types in the mouse primary motor cortex is presented, including a population of excitatory neurons that resemble pyramidal cells in layer 4.

TL;DR: The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally conserved across mammals, and a broadly conserved cellular makeup is demonstrated, whose similarity mirrors evolutionary distance and is consistent between the transcriptome and epigenome.