K
Karla Eggert
Researcher at University of Marburg
Publications - 91
Citations - 4831
Karla Eggert is an academic researcher from University of Marburg. The author has contributed to research in topics: Parkinson's disease & Randomized controlled trial. The author has an hindex of 34, co-authored 88 publications receiving 4283 citations. Previous affiliations of Karla Eggert include Sapienza University of Rome.
Papers
More filters
Journal ArticleDOI
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
Alexander Gerhard,Nicola Pavese,Gary Hotton,Federico Turkheimer,Meltem Es,Alexander Hammers,Karla Eggert,Wolfgang H. Oertel,Richard B. Banati,Richard B. Banati,David J. Brooks +10 more
TL;DR: In vivo findings confirm that widespread microglial activation is associated with the pathological process in PD and suggest that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release.
Journal ArticleDOI
The natural history of multiple system atrophy: a prospective European cohort study
Gregor K. Wenning,Felix Geser,Felix Geser,Florian Krismer,Klaus Seppi,Susanne Duerr,Sylvia Boesch,Martin Köllensperger,Georg Goebel,Karl P. Pfeiffer,Karl P. Pfeiffer,Paolo Barone,Maria Teresa Pellecchia,Niall Quinn,Vasiliki Koukouni,Clare J. Fowler,Anette Schrag,Christopher J. Mathias,Nir Giladi,Tanya Gurevich,Erik Dupont,Karen Østergaard,Christer Nilsson,Håkan Widner,Wolfgang H. Oertel,Karla Eggert,Alberto Albanese,Francesca Del Sorbo,Eduardo Tolosa,Adriana Cardozo,Günther Deuschl,Helge Hellriegel,Thomas Klockgether,Richard Dodel,Cristina Sampaio,Miguel Coelho,Ruth Djaldetti,Eldad Melamed,Thomas Gasser,Christoph Kamm,Christoph Kamm,Giuseppe Meco,Carlo Colosimo,Olivier Rascol,Wassilios G. Meissner,François Tison,Werner Poewe +46 more
TL;DR: The final analysis of a prospective multicentre study by the European MSA Study Group provides new insights into the evolution of MSA based on a follow-up period that exceeds that of previous studies.
Journal ArticleDOI
Predictors of freezing in Parkinson's disease: A survey of 6,620 patients
Michael Macht,Yvonne Kaussner,Jens Carsten Möller,Karin Stiasny-Kolster,Karla Eggert,Hans-Peter Krüger,Heiner Ellgring +6 more
TL;DR: The results underline the necessity to develop appropriate countermeasures against freezing, which is widely known to cause significant impairment of patients' quality of life and—as the data showed—may cause traffic accidents in licensed patients.
Journal ArticleDOI
AFQ056 treatment of levodopa-induced dyskinesias: Results of 2 randomized controlled trials
Daniela Berg,Jana Godau,Claudia Trenkwalder,Karla Eggert,IIona Csoti,Alexander Storch,Heiko Huber,Monica Morelli-Canelo,Maria Stamelou,Vincent Ries,Martin Wolz,Christine Schneider,Thérèse Di Paolo,Fabrizio Gasparini,Sam Hariry,Marc Vandemeulebroecke,Walid M. Abi-Saab,Katy Cooke,Donald Johns,Baltazar Gomez-Mancilla +19 more
TL;DR: AFQ056 showed a clinically relevant and significant antidyskinetic effect without changing the antiparkinsonian effects of dopaminergic therapy and showed significant improvements in dyskinesias on day 16 versus placebo.
Journal ArticleDOI
Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [11C] (R)-PK11195 PET (MEMSA-trial)
Richard Dodel,Richard Dodel,Annika Spottke,Alexander Gerhard,Alexander Gerhard,Alexander Reuss,Sylvia Reinecker,Nicole Schimke,Claudia Trenkwalder,Friederike Sixel-Döring,B. Herting,Christoph Kamm,Christoph Kamm,Thomas Gasser,Martin Sawires,Felix Geser,Martin Köllensperger,Klaus Seppi,Manja Kloss,Martin Krause,C. Daniels,Günther Deuschl,Silke Böttger,Markus Naumann,Axel Lipp,Doreen Gruber,Andreas Kupsch,Yansheng Du,Federico Turkheimer,David J. Brooks,Thomas Klockgether,Werner Poewe,Gregor K. Wenning,Carmen Schade-Brittinger,Wolfgang H. Oertel,Karla Eggert +35 more
TL;DR: This prospective, 48 week, randomized, double‐blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function, and preliminary PET‐data suggest that minocyCline may interfere with microglial activation.