Katharina Domschke

TL;DR: Results provide first insight into cognitive-neurophysiological effects of the GRIN2B C2664T polymorphism and suggest a differential importance of N-methyl-D-aspartate receptors for glutamatergic neural transmission in different striatal compartments (matrix and striosomes).

TL;DR: This review offers a brief outline of psychiatric epigenetics and a comprehensive overview of recent findings exploring the relationship of various occupational stressors and DNA methylation in epigenome-wide association studies (EWAS) and in candidate gene studies including the serotonin transporter, melatonin receptor 1A, MTNR1A, brain-derived neurotrophic factor, tyrosine hydroxylase, and the protein family of DNA methyltransferases (DNMTs).

TL;DR: H hippocampal DNA methylation patterns and expression profiles of female prenatally stressed 5-Htt+/− mice suggest that distinct molecular mechanisms, some of which are promoter methylation-dependent, contribute to the behavioral effects of the 5- Htt genotype, PS exposure and their interaction.

TL;DR: Examination of whether polygenic scores (PGS) derived from the Big Five personality traits predict treatment response and remission in patients with MDD who were prescribed selective serotonin reuptake inhibitors (SSRIs) showed that the PGS for openness and neuroticism were associated with SSRIs treatment outcomes.

TL;DR: The results of this study translate evidence from animal studies to humans and suggest a central role for HTR1A in differentiating subgroups of patients with anxiety disorders.