L
Lars M. T. Eijssen
Researcher at Maastricht University
Publications - 55
Citations - 1834
Lars M. T. Eijssen is an academic researcher from Maastricht University. The author has contributed to research in topics: WikiPathways : Pathways for the people & Gene. The author has an hindex of 18, co-authored 50 publications receiving 1335 citations. Previous affiliations of Lars M. T. Eijssen include University of Amsterdam & Maastricht University Medical Centre.
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Journal ArticleDOI
WikiPathways : a multifaceted pathway database bridging metabolomics to other omics research
Denise Slenter,Martina Kutmon,Kristina Hanspers,Anders Riutta,Jacob Windsor,Nuno Nunes,Jonathan Mélius,Elisa Cirillo,Susan L. Coort,Daniela Digles,Friederike Ehrhart,Pieter Giesbertz,Marianthi Kalafati,Marvin Martens,Ryan A. Miller,Kozo Nishida,Linda Rieswijk,Andra Waagmeester,Lars M. T. Eijssen,Lars M. T. Eijssen,Chris T. Evelo,Alexander R. Pico,Egon Willighagen +22 more
TL;DR: There is a doubling of the number of annotated metabolite nodes in WikiPathways and an OpenAPI documentation of the authors' web services and the FAIR annotation of resources to increase the interoperability of the knowledge encoded in these pathways and experimental omics data.
Journal ArticleDOI
User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org.
Lars M. T. Eijssen,Magali Jaillard,Michiel E. Adriaens,Stan Gaj,Philip J. de Groot,Michael Müller,Chris T. Evelo +6 more
TL;DR: A freely available tool for QC and pre-processing of Affymetrix gene expression results, extending, integrating and harmonizing functionality of Bioconductor packages that assists newcomers to the field in performing state-of-the-art QC andPre-processing while offering data analysts an integral open-source package.
Journal ArticleDOI
Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder
Bart P. F. Rutten,Eric Vermetten,Eric Vermetten,Eric Vermetten,Christiaan H. Vinkers,Gianluca Ursini,Nikolaos P. Daskalakis,Ehsan Pishva,L. De Nijs,Lotte C Houtepen,Lars M. T. Eijssen,Andrew E. Jaffe,Gunter Kenis,Wolfgang Viechtbauer,D.L.A. van den Hove,D.L.A. van den Hove,K. Schraut,Klaus-Peter Lesch,Klaus-Peter Lesch,Joel E. Kleinman,Thomas M. Hyde,D.R. Weinberger,Leonard C. Schalkwyk,Katie Lunnon,Jonathan Mill,Hagit Cohen,Rachel Yehuda,Dewleen G. Baker,Dewleen G. Baker,Adam X. Maihofer,Adam X. Maihofer,Caroline M. Nievergelt,Caroline M. Nievergelt,Elbert Geuze,Elbert Geuze,Marco P. Boks +35 more
TL;DR: This study pinpoints three novel genomic regions where longitudinal decreases in DNA methylation across the period of exposure to combat trauma marks susceptibility for PTSD.
Journal ArticleDOI
Alzheimer’s disease-associated (hydroxy)methylomic changes in the brain and blood
Roy Lardenoije,Roy Lardenoije,Janou A. Y. Roubroeks,Janou A. Y. Roubroeks,Ehsan Pishva,Ehsan Pishva,Markus Leber,Holger Wagner,Artemis Iatrou,Adam Smith,Rebecca G. Smith,Lars M. T. Eijssen,Luca Kleineidam,Luca Kleineidam,Luca Kleineidam,Amit Kawalia,Per Hoffmann,Per Hoffmann,Tobias Luck,Steffi G. Riedel-Heller,Frank Jessen,Frank Jessen,Wolfgang Maier,Wolfgang Maier,Michael Wagner,Michael Wagner,René Hurlemann,Gunter Kenis,Muhammad Ali,Muhammad Ali,Antonio del Sol,Diego Mastroeni,Diego Mastroeni,Elaine Delvaux,Paul D. Coleman,Jonathan Mill,Jonathan Mill,Bart P. F. Rutten,Katie Lunnon,Alfredo Ramirez,Alfredo Ramirez,Daniel L.A. van den Hove,Daniel L.A. van den Hove +42 more
TL;DR: The implication of genome-wide significant differential methylation of OXT, encoding oxytocin, in two independent cohorts indicates it is a promising target for future studies on early biomarkers and novel therapeutic strategies in AD.
Journal ArticleDOI
Altered gene expression in human placentas after IVF/ICSI.
Ewka C.M. Nelissen,John C.M. Dumoulin,Florence Busato,Loïc Ponger,Lars M. T. Eijssen,Johannes L.H. Evers,Jörg Tost,Aafke P.A. van Montfoort +7 more
TL;DR: An altered imprinted gene expression of H19 and Pleckstrin homology-like domain family A member 2 (PHLDA2), which was not due to LOI, was observed in human placentas after IVF/ICSI and several biological pathways were significantly overrepresented and mostly up-regulated.