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Natalie E. Riddell
Researcher at University of Surrey
Publications - 31
Citations - 2139
Natalie E. Riddell is an academic researcher from University of Surrey. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 19, co-authored 30 publications receiving 1619 citations. Previous affiliations of Natalie E. Riddell include University of Birmingham & University of Arizona.
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Journal ArticleDOI
p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells
Sian M. Henson,Alessio Lanna,Natalie E. Riddell,Ornella Franzese,Richard Macaulay,Stephen J. Griffiths,Daniel J. Puleston,Alexander Scarth Watson,Anna Katharina Simon,Sharon A. Tooze,Arne N. Akbar +10 more
TL;DR: Fundamental metabolic requirements of senescent primary human CD8+ T cells are described and it is demonstrated that p38 MAPK blockade reverses senescence via an mTOR-independent pathway.
Journal ArticleDOI
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial
Edward S. Chambers,Claire S Byrne,Douglas J. Morrison,Kevin G Murphy,Tom Preston,Catriona Tedford,Isabel Garcia-Perez,Sofia Fountana,Jose Ivan Serrano-Contreras,Elaine Holmes,Catherine J. Reynolds,Jordie F Roberts,Rosemary J. Boyton,Daniel M. Altmann,Julie A. K. McDonald,Julian R. Marchesi,Arne N. Akbar,Natalie E. Riddell,Gareth A. Wallis,Gary Frost +19 more
TL;DR: These data demonstrate a distinctive physiological impact of raising colonic propionate delivery in humans, as improvements in insulin sensitivity promoted by IPE and inulin were accompanied with different effects on the plasma metabolome, gut bacterial populations and markers of systemic inflammation.
Journal ArticleDOI
Reversible Senescence in Human CD4+CD45RA+CD27− Memory T Cells
Diletta Di Mitri,Rita I. Azevedo,Rita I. Azevedo,Sian M. Henson,Valentina Libri,Natalie E. Riddell,Richard Macaulay,David Glyn Kipling,Maria V. D. Soares,Luca Battistini,Arne N. Akbar +10 more
TL;DR: The involvement of p38 signaling in CD4+ EMRA T cells was investigated and it was found that the expression of both total and phosphorylated p38 was highest in the EM and EMRA compared with that of other CD4- T cell subsets, significantly enhanced their telomerase activity and survival after TCR activation.
Journal ArticleDOI
Acute exercise mobilises CD8+ T lymphocytes exhibiting an effector-memory phenotype.
John Campbell,Natalie E. Riddell,Victoria E. Burns,Mark Turner,Jet J C S Veldhuijzen van Zanten,Mark T. Drayson,Jos A. Bosch,Jos A. Bosch +7 more
TL;DR: It is found that memory CD8TL that exhibit a high effector and tissue-migrating potential are preferentially mobilised during exercise, which unifies a range of independent observations regarding exercise-induced phenotypic and functional changes in circulating lymphocytes.
Journal ArticleDOI
CMV and Immunosenescence: from basics to clinics
Rafael Solana,Raquel Tarazona,Allison E. Aiello,Arne N. Akbar,Victor Appay,Mark Beswick,Jos A. Bosch,Jos A. Bosch,Carmen Campos,Sara Cantisán,Luka Cicin-Sain,Evelyna Derhovanessian,Sara Ferrando-Martinez,Daniela Frasca,Tamas Fulop,Sheila Govind,Beatrix Grubeck-Loebenstein,Ann B. Hill,Mikko Hurme,Florian Kern,Anis Larbi,Miguel López-Botet,Andrea B. Maier,Janet E. McElhaney,Paul Moss,Elissaveta Naumova,Janko Nikolich-Zugich,Alejandra Pera,Jerrald L. Rector,Natalie E. Riddell,Beatriz Sanchez-Correa,Paolo Sansoni,Delphine Sauce,René A. W. van Lier,George C. Wang,Mark R. Wills,Maciej Zieliński,Graham Pawelec +37 more
TL;DR: Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization ofCMV-specific T cells, impact of CMVs infection and ageing on innate immunity, and finally, most important, the clinical implications of immun Rosenescence and CMV infection.