K
Katja Wassmann
Researcher at University of Paris
Publications - 44
Citations - 2997
Katja Wassmann is an academic researcher from University of Paris. The author has contributed to research in topics: Chromosome segregation & Cohesin. The author has an hindex of 24, co-authored 37 publications receiving 2698 citations. Previous affiliations of Katja Wassmann include French Institute of Health and Medical Research & Hannover Medical School.
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Journal ArticleDOI
The Mad2 spindle checkpoint protein has two distinct natively folded states.
Xuelian Luo,Zhanyun Tang,Guohong Xia,Katja Wassmann,Tomohiro Matsumoto,Josep Rizo,Hongtao Yu +6 more
TL;DR: It is shown that without cofactor binding or covalent modification Mad2 adopts two distinct folded conformations at equilibrium (termed N1-Mad2 and N2-Mad1), suggesting that the unusual two-state behavior of Mad2 is critical for spindle checkpoint signaling.
Journal ArticleDOI
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
Nobuaki Kudo,Katja Wassmann,M. Anger,Melina Schuh,Karin G. Wirth,H. Xu,Wolfgang Helmhart,Hiromi Kudo,Michael J. McKay,Bernard Maro,Bernard Maro,Jan Ellenberg,P. de Boer,Kim Nasmyth +13 more
TL;DR: By expressing Cre recombinase from a zona pellucida promoter, a floxed allele of separase is deleted and prevents removal of Rec8 from chromosome arms and resolution of chiasmata, which hinders extrusion of the first polar body (PBE) and causes female sterility.
Journal ArticleDOI
Metaphase I Arrest upon Activation of the Mad2-Dependent Spindle Checkpoint in Mouse Oocytes
TL;DR: This study shows for the first time that a functional Mad2-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes and investigates the mechanisms ensuring correct separation of chromosomes in meiosis I.
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Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1
Katrin Daniel,Julian Lange,Khaled Hached,Khaled Hached,Jun Fu,Konstantinos Anastassiadis,Ignasi Roig,Ignasi Roig,Howard J. Cooke,A. Francis Stewart,Katja Wassmann,Katja Wassmann,Maria Jasin,Scott Keeney,Attila Tóth +14 more
TL;DR: This work shows that mouse HORMAD1 ensures that sufficient numbers of processed DSBs are available for successful homology search, and proposes that the synaptonemal complex and HORMad1 are key components of a negative feedback loop that coordinates meiotic progression with homologue alignment.
Journal ArticleDOI
Mitotic checkpoints: from yeast to cancer.
Katja Wassmann,Robert Benezra +1 more
TL;DR: Molecular mechanisms controlling this checkpoint have been identified and loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.