K
Katsutoshi Goto
Researcher at University of Tsukuba
Publications - 231
Citations - 31742
Katsutoshi Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Endothelin receptor. The author has an hindex of 63, co-authored 228 publications receiving 31015 citations. Previous affiliations of Katsutoshi Goto include University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
Journal ArticleDOI
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Akihiro Inoue,Masashi Yanagisawa,Sadao Kimura,Yoshitoshi Kasuya,Takashi Miyauchi,Katsutoshi Goto,Tomoh Masaki +6 more
TL;DR: Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endotheli sequence, suggesting the possible existence of endothelins receptor subtypes.
Journal ArticleDOI
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor.
Takeshi Sakurai,Masashi Yanagisawa,Yoh Takuwa,Hitoshi Miyazaki,Sadao Kimura,Katsutoshi Goto,Tomoh Masaki +6 more
TL;DR: The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor.
Journal ArticleDOI
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Junko Hara,Carsten T. Beuckmann,Tadahiro Nambu,Jon T. Willie,Richard M. Chemelli,Christopher M. Sinton,Fumihiro Sugiyama,Ken-ichi Yagami,Katsutoshi Goto,Masashi Yanagisawa,Takeshi Sakurai +10 more
TL;DR: Evidence is provided that orexin-containing neurons play important roles in regulating vigilance states and energy homeostasis and the pathophysiology and treatment of narcolepsy.
Journal ArticleDOI
Distribution of orexin neurons in the adult rat brain.
Tadahiro Nambu,Takeshi Sakurai,Katsuyoshi Mizukami,Yasuhiko Hosoya,Masashi Yanagisawa,Katsutoshi Goto +5 more
TL;DR: A further study of the distribution of ORX-containing neurons in the adult rat brain to provide a general overview of the ORX neuronal system was conducted in this article. But, the results were limited to the lateral hypothalamic area (LHA) and dorsomedial hypothalamic nucleus (DMH), the regions classically implicated in feeding behavior.