K
Kenji Okita
Researcher at Sapporo Medical University
Publications - 75
Citations - 1420
Kenji Okita is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 16, co-authored 68 publications receiving 1070 citations.
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Journal ArticleDOI
Association of Fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway
Miki Ito,Shinichi Kanno,Katsuhiko Nosho,Yasutaka Sukawa,Kei Mitsuhashi,Hiroyoshi Kurihara,Hisayoshi Igarashi,Taiga Takahashi,Mami Tachibana,Hiroaki Takahashi,Shinji Yoshii,Toshinao Takenouchi,Tadashi Hasegawa,Kenji Okita,Koichi Hirata,Reo Maruyama,Hiromu Suzuki,Kohzoh Imai,Hiroyuki Yamamoto,Yasuhisa Shinomura +19 more
TL;DR: The presence of F. nucleatum was identified in premalignant colorectal lesions regardless of histopathology but was more frequently associated with CIMP‐high lesions, and its positivity increased according to histological grade, suggesting that it may contribute to the progression of coloreCTal neoplasia.
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RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated
Atsushi Tanabe,Kenya Tanikawa,Mai Tsunetomi,Kaori Takai,Hiroto Ikeda,Junpei Konno,Toshihiko Torigoe,Hideki Maeda,Goro Kutomi,Kenji Okita,Mitsuru Mori,Hiroeki Sahara +11 more
TL;DR: It is suggested that the RNA helicase YTH DC2 contributes to colon tumor metastasis by promoting translation of HIF-1α and that YTHDC2 is potentially a diagnostic marker and target gene for treating colon cancer patients.
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Association of microRNA-31 with BRAF mutation, colorectal cancer survival and serrated pathway.
Katsuhiko Nosho,Hisayoshi Igarashi,Masanori Nojima,Miki Ito,Reo Maruyama,Shinji Yoshii,Takafumi Naito,Yasutaka Sukawa,Masashi Mikami,Wakana Sumioka,Eiichiro Yamamoto,Sei Kurokawa,Yasushi Adachi,Hiroaki Takahashi,Hiroyuki Okuda,Takaya Kusumi,Masao Hosokawa,Masahiro Fujita,Tadashi Hasegawa,Kenji Okita,Koichi Hirata,Hiromu Suzuki,Hiroyuki Yamamoto,Yasuhisa Shinomura +23 more
TL;DR: In this paper, the authors identify a relationship between specific miRNA molecules and BRAF mutation in colorectal cancers and serrated lesions and demonstrate that miR-31 inhibitor decreased cell invasion and proliferation.
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Japanese Society of Clinical Oncology clinical practice guidelines 2010 for antiemesis in oncology: executive summary
Hideki Takeuchi,Toshiaki Saeki,Keisuke Aiba,Kazuo Tamura,Kenjiro Aogi,Kenji Eguchi,Kenji Okita,Yoshikazu Kagami,Ryuhei Tanaka,Kazuhiko Nakagawa,Hirofumi Fujii,Narikazu Boku,Makoto Wada,Tatsuo Akechi,Yasuhiro Udagawa,Yutaka Okawa,Yusuke Onozawa,Hidenori Sasaki,Yasuo Shima,Naohito Shimoyama,Masayuki Takeda,Toshihiko Nishidate,Akifumi Yamamoto,Tadashi Ikeda,Koichi Hirata +24 more
TL;DR: The 2010 JSCO clinical practice guidelines for antiemesis are presented in English and reveal high concordance of Japanese medical circumstances with other antiemetic guidelines that are similarly based on evidence.
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Association of MicroRNA-31-5p with Clinical Efficacy of Anti-EGFR Therapy in Patients with Metastatic Colorectal Cancer
Hisayoshi Igarashi,Hiroyoshi Kurihara,Kei Mitsuhashi,Miki Ito,Hiroyuki Okuda,Shinichi Kanno,Takafumi Naito,Shinji Yoshii,Hiroaki Takahashi,Takaya Kusumi,Tadashi Hasegawa,Yasutaka Sukawa,Yasutaka Sukawa,Yasushi Adachi,Kenji Okita,Koichi Hirata,Yu Imamura,Yoshifumi Baba,Kohzoh Imai,Hiromu Suzuki,Hiroyuki Yamamoto,Katsuhiko Nosho,Yasuhisa Shinomura +22 more
TL;DR: High miR-31-5p expression was associated with shorter PFS in patients with CRC treated with anti-EGFR therapeutics, suggesting that it may be a useful and additional prognostic biomarker for anti- EGFR therapy.