Kevin M. McBride

TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.

TL;DR: The experiments show that Polq-null murine cells are selectively hypersensitive to DNA strand breaking agents, and that damage resistance requires the DNA polymerase activity of POLQ, and depart from the prevailing view that alternative end joining processes are generically translocation-prone.

TL;DR: By reducing negative supercoiling and resolving R loops, TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations.

TL;DR: This work has targeted the DNA damage response protein, 53BP1, which uses its tandem tudor domain to recognize histone H4 dimethylated on lysine 20 (H4K20me2), a modification related to double-strand DNA breaks and shows cellular activity by suppressing class switch recombination.

TL;DR: The POLQ-associated mutation signatures in human cancers are defined, characterized by short insertions and deletions in a specific range of microhomologies, and it is shown that TMEJ dominates end joining of two separated DSBs (distal EJ), which will aid in identifying tumors relying on POLQ activity.