K
Kiichiro Tomoda
Researcher at Osaka Medical College
Publications - 33
Citations - 24267
Kiichiro Tomoda is an academic researcher from Osaka Medical College. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 18, co-authored 30 publications receiving 21439 citations. Previous affiliations of Kiichiro Tomoda include University of California, San Francisco & Gladstone Institutes.
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Journal ArticleDOI
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
Journal ArticleDOI
Induction of Pluripotent Stem Cells From Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: This work generated induced pluripotent stem cells capable of germline transmission from murine somatic cells by transd, and demonstrated the ability of these cells to reprogram into patient-specific and disease-specific stem cells.
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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1
TL;DR: It is found that a mouse 38K protein (p38) encoded by the Jab1 gene interacts specifically with p27Kip1 and it is shown that overexpression of p38 in mammalian cells causes the translocation of p27kip1 from the nucleus to the cytoplasm, decreasing the amount of p 27Kip 1 in the cell by accelerating its degradation.
Journal ArticleDOI
The Cytoplasmic Shuttling and Subsequent Degradation of p27Kip1 Mediated by Jab1/CSN5 and the COP9 Signalosome Complex
Kiichiro Tomoda,Yukiko Kubota,Yukinobu Arata,Seiji Mori,Maki Maeda,Toshiaki Tanaka,Minoru Yoshida,Noriko Yoneda-Kato,Jun-ya Kato +8 more
TL;DR: Results indicate that cytoplasmic shuttling regulated by Jab1/CSN5 and other CSN components may be a new pathway to control the intracellular abundance of the key cell cycle regulator.
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Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.
TL;DR: Jab1 controls cell cycle progression and cell survival by regulating multiple cell cycle signaling pathways via deneddylation of cullin subunit of the Skp1-Cullin-F box protein ubiquitin ligase complex.