Kirstin Mösbauer

TL;DR: The results indicate that chloroquine targets a pathway for viral activation that is not active in lung cells and is unlikely to protect against the spread of SARS-CoV-2 in and between patients.

TL;DR: It is shown that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.

TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.

TL;DR: In vitro cell culture models are established to study SARS-CoV-2 infection and heat shock protein 90 (HSP90) protein is identified as a potential drug target for therapeutic intervention of Sars-CoVs infection.

TL;DR: The results of this study revealed that coronavirus PLP confers a variable virulence trait among members of the species SARS-CoV, and that a Sars- coV lineage with virulent PLPs may have pre-existed in the reservoir before onset of the epidemic.