K
Klaus Gerth
Researcher at University of Washington
Publications - 111
Citations - 6652
Klaus Gerth is an academic researcher from University of Washington. The author has contributed to research in topics: Sorangium cellulosum & Myxobacteria. The author has an hindex of 44, co-authored 111 publications receiving 6204 citations.
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Journal ArticleDOI
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
TL;DR: An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum strain So ce90 and the epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol.
Journal ArticleDOI
Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution†
Gerhard Höfle,Norbert Bedorf,Heinrich Steinmetz,Dietmar Schomburg,Klaus Gerth,Hans Reichenbach +5 more
Journal ArticleDOI
Complete genome sequence of the myxobacterium Sorangium cellulosum
Susanne Schneiker,Olena Perlova,Olaf Kaiser,Klaus Gerth,Aysel Alici,Matthias Altmeyer,Daniela Bartels,Thomas Bekel,Stefan Beyer,Edna Bode,Helge B. Bode,Christoph J. Bolten,Jomuna V. Choudhuri,Sabrina D. Doss,Yasser A. Elnakady,Bettina Frank,Lars Gaigalat,Alexander Goesmann,Carolin Groeger,Frank Gross,Lars Jelsbak,Lotte Jelsbak,Jörn Kalinowski,Carsten Kegler,Tina Knauber,Sebastian Konietzny,Maren Kopp,Lutz Krause,Daniel Krug,Bukhard Linke,Taifo Mahmud,Rosa Martínez-Arias,Alice C. McHardy,Michelle Merai,Folker Meyer,Sascha Mormann,José Muñoz-Dorado,Juana Pérez,Silke Pradella,Shwan Rachid,Günter Raddatz,Frank Rosenau,Christian Rückert,Florenz Sasse,Maren Scharfe,Stephan C. Schuster,Garret Suen,Anke Treuner-Lange,Gregory J. Velicer,Frank-Jörg Vorhölter,Kira J. Weissman,Roy D. Welch,Silke C. Wenzel,David E. Whitworth,Susanne Wilhelm,Christoph Wittmann,Helmut Blöcker,Alfred Pühler,Rolf Müller +58 more
TL;DR: The complete genome sequence of the model Sorangium strain S. cellulosum So ce56 is reported, which produces several natural products and has morphological and physiological properties typical of the genus, and the circular genome is the largest bacterial genome sequenced to date.
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Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium.
TL;DR: Recent and future biotechnological research on certain key myxobacteria and on their ability to produce natural products is reviewed with the focus on the production of myxovirescin, soraphen and epothilone.
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Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2
TL;DR: The new fast growing myxobacterial thermophilic isolate GT-2 is described as a heterologous host for the expression of natural product biosynthetic pathways isolated from other myXobacteria.