Y
Yu Tang Gao
Researcher at Fudan University
Publications - 39
Citations - 8294
Yu Tang Gao is an academic researcher from Fudan University. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 30, co-authored 39 publications receiving 7346 citations. Previous affiliations of Yu Tang Gao include Karolinska Institutet & Shanghai Jiao Tong University.
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Journal ArticleDOI
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Kyriaki Michailidou,Per Hall,Anna González-Neira,Maya Ghoussaini,Joe Dennis,Roger L. Milne,Marjanka K. Schmidt,Jenny Chang-Claude,Stig E. Bojesen,Manjeet K. Bolla,Qin Wang,Ed Dicks,Andy C. H. Lee,Clare Turnbull,Nazneen Rahman,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos Santos Silva,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Kamila Czene,Astrid K. Irwanto,Jianjun Liu,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Rebecca Hein,N. Dahmen,Lars Beckman,Alfons Meindl,Rita K. Schmutzler,Bertram Müller-Myhsok,Peter Lichtner,John L. Hopper,Melissa C. Southey,Enes Makalic,Daniel F. Schmidt,Andre G. Uitterlinden,Albert Hofman,David J. Hunter,Stephen J. Chanock,Daniel Vincent,Francois Bacot,Daniel C. Tessier,Sander Canisius,Lodewyk F. A. Wessels,Christopher A. Haiman,Mitul Shah,Robert Luben,Judith E. Brown,Craig Luccarini,Nils Schoof,Keith Humphreys,Jingmei Li,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Fergus J. Couch,Xianshu Wang,Celine M. Vachon,Kristen N. Stevens,Diether Lambrechts,Matthieu Moisse,Robert Paridaens,Marie Rose Christiaens,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Dieter Flesch-Janys,Nichola Johnson,Zoe Aitken,Kirsimari Aaltonen,Kirsimari Aaltonen,Tuomas Heikkinen,Annegien Broeks,Laura J. Van 'T Veer,C. Ellen van der Schoot,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,M. Pilar Zamora,Jose Ignacio Arias Perez,Guillermo Pita,M. Rosario Alonso,Angela Cox,Ian W. Brock,Simon S. Cross,Malcolm W.R. Reed,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Annika Lindblom,Sara Margolin,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Quang M. Bui,Jennifer Stone,Gillian S. Dite,Carmel Apicella,Helen Tsimiklis,Graham G. Giles,Gianluca Severi,Laura Baglietto,Peter A. Fasching,Lothar Haeberle,Arif B. Ekici,Matthias W. Beckmann,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Michael Jones,Jonine D. Figueroa,Jolanta Lissowska,Louise A. Brinton,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Bernardo Bonanni,Peter Devilee,Rob A. E. M. Tollenaar,Caroline M. Seynaeve,Christi J. van Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Durda,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Vessela N. Kristensen,Hoda Anton-Culver,Susan L. Slager,Amanda E. Toland,Stephen Edge,Florentia Fostira,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Soo Hwang Teo,Cheng Har Yip,Sze Yee Phuah,Belinda K. Cornes,Mikael Hartman,Hui Miao,Wei-Yen Lim,J. H. Sng,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shian Ling Ding,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,William Blot,Lisa B. Signorello,Qiuyin Cai,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Jacques Simard,M Garcia-Closas,Paul D.P. Pharoah,Georgia Chenevix-Trench,Alison M. Dunning,Javier Benitez,Douglas F. Easton +220 more
TL;DR: A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
Journal ArticleDOI
Association analysis identifies 65 new breast cancer risk loci
Kyriaki Michailidou,Kyriaki Michailidou,Sara Lindström,Sara Lindström,Joe Dennis,Jonathan Beesley,Shirley Hui,Siddhartha Kar,Audrey Lemaçon,Penny Soucy,Dylan M. Glubb,Asha Rostamianfar,Manjeet K. Bolla,Qin Wang,Jonathan Tyrer,Ed Dicks,Andy C. H. Lee,Zhaoming Wang,Jamie Allen,Renske Keeman,Ursula Eilber,Juliet D. French,Xiaoqing Chen,Laura Fachal,Karen McCue,Amy E. McCart Reed,Maya Ghoussaini,Jason S. Carroll,Xia Jiang,Hilary K. Finucane,Hilary K. Finucane,Marcia Adams,Muriel A. Adank,Habibul Ahsan,Kristiina Aittomäki,Hoda Anton-Culver,Natalia Antonenkova,Volker Arndt,Kristan J. Aronson,Banu Arun,Paul L. Auer,Paul L. Auer,Francois Bacot,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Sabine Behrens,Javier Benitez,Marina Bermisheva,Leslie Bernstein,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Stig E. Bojesen,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Paul Brennan,Hermann Brenner,Louise A. Brinton,Per Broberg,Ian W. Brock,Annegien Broeks,Angela Brooks-Wilson,Angela Brooks-Wilson,Sara Y. Brucker,Thomas Brüning,Barbara Burwinkel,Barbara Burwinkel,Katja Butterbach,Qiuyin Cai,Hui Cai,Trinidad Caldés,Federico Canzian,Angel Carracedo,Brian D. Carter,Jose E. Castelao,Tsun Leung Chan,Tongguang Cheng,Kee Seng Chia,Ji Yeob Choi,Hans Christiansen,Christine L. Clarke,Margriet Collée,Don M. Conroy,Emilie Cordina-Duverger,Sten Cornelissen,David G. Cox,David G. Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Lorraine Durcan,Miriam Dwek,Diana Eccles,Arif B. Ekici,A. Heather Eliassen,A. Heather Eliassen,Carolina Ellberg,Mingajeva Elvira,Christoph Engel,Mikael Eriksson,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Valerie Gaborieau,Marike Gabrielson,Manuela Gago-Dominguez,Yu Tang Gao,Susan M. Gapstur,José A. García-Sáenz,Mia M. Gaudet,Vassilios Georgoulias,Graham G. Giles,Graham G. Giles,Gord Glendon,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Grethe I. Grenaker Alnæs,Mervi Grip,Jacek Gronwald,Anne Grundy,Pascal Guénel,Lothar Haeberle,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Ute Hamann,N Hamel,Susan E. Hankinson,Patricia Harrington,Steven N. Hart,Jaana M. Hartikainen,Mikael Hartman,Mikael Hartman,Alexander Hein,Jane Heyworth,Belynda Hicks,Peter Hillemanns,Dona N. Ho,Antoinette Hollestelle,Maartje J. Hooning,Robert N. Hoover,John L. Hopper,Ming-Feng Hou,Chia-Ni Hsiung,Guanmengqian Huang,Keith Humphreys,Junko Ishiguro,Hidemi Ito,Motoki Iwasaki,Hiroji Iwata,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Arja Jukkola-Vuorinen,Rudolf Kaaks,Maria Kabisch,Katarzyna Kaczmarek,Daehee Kang,Daehee Kang,Yoshio Kasuga,Michael J. Kerin,Sofia Khan,Elza Khusnutdinova,Elza Khusnutdinova,Johanna I. Kiiski,Sung-Won Kim,Julia A. Knight,Julia A. Knight,Veli-Matti Kosma,Vessela N. Kristensen,Vessela N. Kristensen,Ute Krüger,Ava Kwong,Diether Lambrechts,Loic Le Marchand,Eunjung Lee,Min Hyuk Lee,Jong Won Lee,Chuen Neng Lee,Flavio Lejbkowicz,Jingmei Li,Jenna Lilyquist,Annika Lindblom,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jirong Long,Artitaya Lophatananon,Artitaya Lophatananon,Jan Lubinski,Craig Luccarini,Michael P. Lux,Edmond S. K. Ma,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Enes Makalic,Kathleen E. Malone,Ivana Maleva Kostovska,Arto Mannermaa,Siranoush Manoukian,JoAnn E. Manson,JoAnn E. Manson,Sara Margolin,Shivaani Mariapun,Maria Elena Martinez,Keitaro Matsuo,Dimitrios Mavroudis,James McKay,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Primitiva Menéndez,Usha Menon,J.-P. Meyer,Hui Miao,Nicola Miller,Nur Aishah Taib,Kenneth Muir,Kenneth Muir,Anna Marie Mulligan,Anna Marie Mulligan,Claire Mulot,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Dong-Young Noh,Børge G. Nordestgaard,Børge G. Nordestgaard,Aaron D. Norman,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Curtis Olswold,Nick Orr,V. Shane Pankratz,Sue K. Park,Sue K. Park,Tjoung-Won Park-Simon,Rachel Lloyd,Jose Ignacio Arias Perez,Paolo Peterlongo,Julian Peto,Kelly-Anne Phillips,Mila Pinchev,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Darya Prokofyeva,Elizabeth W. Pugh,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gadi Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Jane Romm,Kathryn J. Ruddy,Thomas Rüdiger,Anja Rudolph,Matthias Ruebner,Emiel J. Th. Rutgers,Emmanouil Saloustros,Dale P. Sandler,Suleeporn Sangrajrang,Elinor J. Sawyer,Daniel F. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Minouk J. Schoemaker,Fredrick R. Schumacher,Peter Schürmann,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Caroline Seynaeve,Mitul Shah,Priyanka Sharma,Chen-Yang Shen,Chen-Yang Shen,Grace Sheng,Mark E. Sherman,Martha J. Shrubsole,Xiao-Ou Shu,Ann Smeets,Christof Sohn,Melissa C. Southey,John J. Spinelli,John J. Spinelli,Christa Stegmaier,Sarah Stewart-Brown,Jennifer Stone,Jennifer Stone,Daniel O. Stram,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,Rulla M. Tamimi,Jack A. Taylor,Maria Tengström,Soo Hwang Teo,Mary Beth Terry,Daniel C. Tessier,Somchai Thanasitthichai,Kathrin Thöne,Rob A. E. M. Tollenaar,Ian Tomlinson,Ling Tong,Diana Torres,Diana Torres,Thérèse Truong,Chiu-Chen Tseng,Shoichiro Tsugane,Hans-Ulrich Ulmer,Giske Ursin,Michael Untch,Celine M. Vachon,Christi J. van Asperen,David Van Den Berg,Ans M.W. van den Ouweland,Lizet E. van der Kolk,Rob B. van der Luijt,Daniel Vincent,Jason Vollenweider,Quinten Waisfisz,Shan Wang-Gohrke,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Anna H. Wu,Lucy Xia,Taiki Yamaji,Xiaohong R. Yang,Cheng Har Yip,Keun-Young Yoo,Jyh-Cherng Yu,Wei Zheng,Ying Zheng,Bin Zhu,Argyrios Ziogas,Elad Ziv,Sunil R. Lakhani,Sunil R. Lakhani,Antonis C. Antoniou,Arnaud Droit,Irene L. Andrulis,Irene L. Andrulis,Christopher I. Amos,Fergus J. Couch,Paul D.P. Pharoah,Jenny Chang-Claude,Jenny Chang-Claude,Per Hall,David J. Hunter,Roger L. Milne,Roger L. Milne,Montserrat Garcia-Closas,Marjanka K. Schmidt,Stephen J. Chanock,Alison M. Dunning,Stacey L. Edwards,Gary D. Bader,Georgia Chenevix-Trench,Jacques Simard,Peter Kraft,Douglas F. Easton +396 more
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.
Journal ArticleDOI
Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians
Wei Zheng,Dale McLerran,Betsy Rolland,Xianglan Zhang,Manami Inoue,Keitaro Matsuo,Jiang He,Prakash C. Gupta,Kunnambath Ramadas,Shoichiro Tsugane,Fujiko Irie,Akiko Tamakoshi,Yu Tang Gao,Renwei Wang,Xiao-Ou Shu,Ichiro Tsuji,Shinichi Kuriyama,Hideo Tanaka,Hiroshi Satoh,Chien-Jen Chen,Chien-Jen Chen,Jian-Min Yuan,Keun-Young Yoo,Habibul Ahsan,Wen-Harn Pan,Wen-Harn Pan,Dongfeng Gu,Mangesh S. Pednekar,Catherine Sauvaget,Shizuka Sasazuki,Toshimi Sairenchi,Gong Yang,Yong-Bing Xiang,Masato Nagai,Takeshi Suzuki,Yoshikazu Nishino,San Lin You,Woon-Puay Koh,Sue K. Park,Yu Chen,Chen-Yang Shen,Chen-Yang Shen,Mark D. Thornquist,Ziding Feng,Daehee Kang,Paolo Boffetta,John D. Potter +46 more
TL;DR: Underweight was associated with a substantially increased risk of death in all Asian populations, however, the excess risk of died was seen among East Asians but not among Indians and Bangladeshis.
Journal ArticleDOI
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Kyriaki Michailidou,Jonathan Beesley,Sara Lindström,Sander Canisius,Joe Dennis,Michael Lush,Mel Maranian,Manjeet K. Bolla,Qin Wang,Mitul Shah,Barbara Perkins,Kamila Czene,Mikael Eriksson,Hatef Darabi,Judith S. Brand,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Henrik Flyger,Sune F. Nielsen,Nazneen Rahman,Clare Turnbull,Olivia Fletcher,Julian Peto,Lorna Gibson,Isabel dos-Santos-Silva,Jenny Chang-Claude,Dieter Flesch-Janys,Anja Rudolph,Ursula Eilber,Sabine Behrens,Heli Nevanlinna,Taru A. Muranen,Taru A. Muranen,Kristiina Aittomäki,Kristiina Aittomäki,Carl Blomqvist,Carl Blomqvist,Sofia Khan,Sofia Khan,Kirsimari Aaltonen,Kirsimari Aaltonen,Habibul Ahsan,Muhammad G. Kibriya,Alice S. Whittemore,Esther M. John,Kathleen E. Malone,Marilie D. Gammon,Marilie D. Gammon,Regina M. Santella,Giske Ursin,Giske Ursin,Enes Makalic,Daniel F. Schmidt,Graham Casey,David J. Hunter,Susan M. Gapstur,Mia M. Gaudet,W. Ryan Diver,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Christine D. Berg,Stephen J. Chanock,Jonine D. Figueroa,Robert N. Hoover,Diether Lambrechts,Patrick Neven,Patrick Neven,Hans Wildiers,Erik Van Limbergen,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Fergus J. Couch,Janet E. Olson,Emily Hallberg,Emily Hallberg,Emily Hallberg,Celine M. Vachon,Quinten Waisfisz,Quinten Waisfisz,Hanne Meijers-Heijboer,Muriel A. Adank,Rob B. van der Luijt,Jingmei Li,Jianjun Liu,Jianjun Liu,Keith Humphreys,Keith Humphreys,Daehee Kang,Ji Yeob Choi,Sue K. Park,Keun-Young Yoo,Keun-Young Yoo,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Pascal Guénel,Thérèse Truong,Claire Mulot,Marie Sanchez,Barbara Burwinkel,Frederik Marme,Harald Surowy,Christof Sohn,Anna H. Wu,Chiu-Chen Tseng,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Anna González-Neira,Javier Benitez,M. Pilar Zamora,Jose Ignacio Arias Perez,Xiao-Ou Shu,Xiao-Ou Shu,Wei Lu,Wei Lu,Wei Lu,Yu Tang Gao,Yu Tang Gao,Yu Tang Gao,Hui Cai,Hui Cai,Angela Cox,Simon S. Cross,Malcolm W.R. Reed,Irene L. Andrulis,Julia A. Knight,Julia A. Knight,Gord Glendon,Gord Glendon,Anna Marie Mulligan,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Annika Lindblom,Sara Margolin,Soo Hwang Teo,Cheng Har Yip,Nur Aishah Taib,Gie Hooi Tan,Maartje J. Hooning,Antoinette Hollestelle,John W. M. Martens,J. Margriet Collée,William Blot,Lisa B. Signorello,Qiuyin Cai,John L. Hopper,John L. Hopper,Melissa C. Southey,Helen Tsimiklis,Carmel Apicella,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Pei Ei Wu,Ming-Feng Hou,Vessela N. Kristensen,Silje Nord,Grethe I. Grenaker Alnæs,Graham G. Giles,Roger L. Milne,Catriona McLean,Catriona McLean,Federico Canzian,Federico Canzian,Dimitrios Trichopoulos,Petra P.H. Peeters,Eiliv Lund,Malin Sund,Kay-Tee Khaw,Marc J. Gunter,Domenico Palli,Lotte Maxild Mortensen,Laure Dossus,José María Huerta,José María Huerta,A. Meindl,Rita K. Schmutzler,Christian Sutter,Rongxi Yang,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Sarah Stewart-Brown,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Pornthep Siriwanarangsan,Mikael Hartman,Hui Miao,Kee Seng Chia,Ching Wan Chan,Peter A. Fasching,Alexander Hein,Matthias W. Beckmann,Lothar Haeberle,Hermann Brenner,Aida Karina Dieffenbach,Volker Arndt,Christa Stegmaier,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Anthony J. Swerdlow,Louise A. Brinton,Montserrat Garcia-Closas,Wei Zheng,Sandra L. Halverson,Martha J. Shrubsole,Martha J. Shrubsole,Jirong Long,Jirong Long,Mark S. Goldberg,Martine Dumont,Robert Winqvist,Katri Pylkäs,Katri Pylkäs,Arja Jukkola-Vuorinen,Arja Jukkola-Vuorinen,Mervi Grip,Mervi Grip,Hiltrud Brauch,Ute Hamann,Thomas Brüning,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Natalia Bogdanova,Natalia Bogdanova,Thilo Dörk,Thilo Dörk,Arto Mannermaa,Arto Mannermaa,Vesa Kataja,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Christi J Asperen,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Tomasz Huzarski,Suleeporn Sangrajrang,Suleeporn Sangrajrang,Valerie Gaborieau,Paul Brennan,James McKay,Susan L. Slager,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Maria Kabisch,Diana Torres,Susan L. Neuhausen,Hoda Anton-Culver,Craig Luccarini,Caroline Baynes,S. Ahmed,Catherine S. Healey,Daniel C. Tessier,Daniel Vincent,Francois Bacot,G Pita,M. Rosario Alonso,Nuria Álvarez,Daniel Herrero,Jacques Simard,Paul D.P. Pharoah,Peter Kraft,Alison M. Dunning,Georgia Chenevix-Trench,Per Hall,Douglas F. Easton +283 more
TL;DR: 15 new loci associated with breast cancer at P < 5 × 10−8 are identified, and one association appears to be driven by an amino acid substitution encoded in EXO1, which is found in women of European ancestry.
Journal ArticleDOI
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Stig E. Bojesen,Stig E. Bojesen,Karen A. Pooley,Sharon E. Johnatty,Jonathan Beesley,Kyriaki Michailidou,Jonathan Tyrer,Stacey L. Edwards,Hilda A. Pickett,Hilda A. Pickett,Howard C. Shen,Chanel E. Smart,Kristine M. Hillman,Phuong L. Mai,Kate Lawrenson,Michael D. Stutz,Michael D. Stutz,Yi Lu,Rod Karevan,Nicholas T. Woods,Rebecca L. Johnston,Juliet D. French,Xiaoqing Chen,Maren Weischer,Sune F. Nielsen,Melanie Maranian,Maya Ghoussaini,Shahana Ahmed,Caroline Baynes,Manjeet K. Bolla,Qin Wang,Joe Dennis,Lesley McGuffog,Daniel Barrowdale,Andrew Lee,Sue Healey,Michael Lush,Daniel C. Tessier,Daniel Vincent,Françis Bacot,Ignace Vergote,Sandrina Lambrechts,Evelyn Despierre,Harvey A. Risch,Anna González-Neira,Mary Anne Rossing,Mary Anne Rossing,Guillermo Pita,Jennifer A. Doherty,Nuria Álvarez,Melissa C. Larson,Brooke L. Fridley,Nils Schoof,Jenny Chang-Claude,Mine S. Cicek,Julian Peto,Kimberly R. Kalli,Annegien Broeks,Sebastian M. Armasu,Marjanka K. Schmidt,Linde M. Braaf,Boris Winterhoff,Heli Nevanlinna,Gottfried E. Konecny,Diether Lambrechts,L. Rogmann,Pascal Guénel,Attila Teoman,Roger L. Milne,Joaquin J. Garcia,Angela Cox,Vijayalakshmi Shridhar,Barbara Burwinkel,Frederik Marmé,Rebecca Hein,Rebecca Hein,Elinor J. Sawyer,Christopher A. Haiman,Shan Wang-Gohrke,Irene L. Andrulis,Kirsten B. Moysich,John L. Hopper,Kunle Odunsi,Annika Lindblom,Graham G. Giles,Graham G. Giles,Graham G. Giles,Hermann Brenner,Jacques Simard,Galina Lurie,Peter A. Fasching,Peter A. Fasching,Michael E. Carney,Paolo Radice,Lynne R. Wilkens,Anthony J. Swerdlow,Marc T. Goodman,Hiltrud Brauch,Hiltrud Brauch,Montserrat Garcia-Closas,Peter Hillemanns,Robert Winqvist,Matthias Dürst,Peter Devilee,Ingo B. Runnebaum,Anna Jakubowska,Jan Lubinski,Arto Mannermaa,Ralf Bützow,Natalia Bogdanova,Thilo Dörk,Liisa M. Pelttari,Wei Zheng,Arto Leminen,Hoda Anton-Culver,Clareann H. Bunker,Vessela N. Kristensen,Roberta B. Ness,Kenneth Muir,Kenneth Muir,Robert Edwards,Alfons Meindl,Florian Heitz,Keitaro Matsuo,Andreas du Bois,Anna H. Wu,Philipp Harter,Soo Hwang Teo,Ira Schwaab,Xiao-Ou Shu,William Blot,Satoyo Hosono,Daehee Kang,Toru Nakanishi,Mikael Hartman,Mikael Hartman,Yasushi Yatabe,Ute Hamann,Beth Y. Karlan,Suleeporn Sangrajrang,Susanne K. Kjaer,Valerie Gaborieau,Allan Jensen,Diana Eccles,Estrid Høgdall,Chen-Yang Shen,Chen-Yang Shen,Judith E. Brown,Yin Ling Woo,Mitul Shah,Mat Adenan Noor Azmi,Robert Luben,Siti Zawiah Omar,Kamila Czene,Robert A. Vierkant,Børge G. Nordestgaard,Henrik Flyger,Celine M. Vachon,Janet E. Olson,Xianshu Wang,Douglas A. Levine,Anja Rudolph,Rachel Palmieri Weber,Dieter Flesch-Janys,Edwin S. Iversen,Stefan Nickels,Joellen M. Schildkraut,Isabel dos Santos Silva,Daniel W. Cramer,Lorna Gibson,Kathryn L. Terry,Olivia Fletcher,Allison F. Vitonis,C. Ellen van der Schoot,Elizabeth M. Poole,Frans B. L. Hogervorst,Shelley S. Tworoger,Jianjun Liu,Elisa V. Bandera,Jingmei Li,Sara H. Olson,Keith Humphreys,Irene Orlow,Carl Blomqvist,Lorna Rodriguez-Rodriguez,Kristiina Aittomäki,Helga B. Salvesen,Taru A. Muranen,Elisabeth Wik,Barbara Brouwers,Camilla Krakstad,Els Wauters,Mari K. Halle,Hans Wildiers,Lambertus A. Kiemeney,Claire Mulot,Katja K.H. Aben,Pierre Laurent-Puig,Anne M. van Altena,Thérèse Truong,Leon F.A.G. Massuger,Javier Benitez,Tanja Pejovic,Jose Ignacio Arias Perez,Maureen E. Hoatlin,M. Pilar Zamora,Linda S. Cook,Sabapathy P. Balasubramanian,Linda E. Kelemen,Andreas Schneeweiss,Nhu D. Le,Christof Sohn,Angela Brooks-Wilson,Angela Brooks-Wilson,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Cezary Cybulski,Brian E. Henderson,Janusz Menkiszak,Fredrick R. Schumacher,Nicolas Wentzensen,Loic Le Marchand,Hannah P. Yang,Anna Marie Mulligan,Gord Glendon,Svend Aage Engelholm,Julia A. Knight,Claus Høgdall,Carmel Apicella,Martin Gore,Helen Tsimiklis,Honglin Song,Melissa C. Southey,Agnes Jager,Ans M Wvan Den Ouweland,Robert S. Brown,John W.M. Martens,James M. Flanagan,Mieke Kriege,James Paul,Sara Margolin,Nadeem Siddiqui,Gianluca Severi,Gianluca Severi,Alice S. Whittemore,Laura Baglietto,Laura Baglietto,Valerie McGuire,Christa Stegmaier,Weiva Sieh,Heiko Müller,Volker Arndt,Yu Tang Gao,Mark S. Goldberg,Gong Yang,Martine Dumont,John R. McLaughlin,Arndt Hartmann,Arif B. Ekici,Matthias W. Beckmann,Catherine M. Phelan,Michael P. Lux,Jenny Permuth-Wey,Bernard Peissel,Thomas A. Sellers,Filomena Ficarazzi,Monica Barile,Argyrios Ziogas,Alan Ashworth,Aleksandra Gentry-Maharaj,Michael Jones,Susan J. Ramus,Nick Orr,Usha Menon,Celeste Leigh Pearce,Thomas Brüning,Malcolm C. Pike,Malcolm C. Pike,Yon Ko,Jolanta Lissowska,Jonine D. Figueroa,Jolanta Kupryjanczyk,Stephen J. Chanock,Agnieszka Dansonka-Mieszkowska,Arja Jukkola-Vuorinen,Iwona K. Rzepecka,Katri Pylkäs,Mariusz Bidziński,Saila Kauppila,Antoinette Hollestelle,Caroline Seynaeve,Rob A. E. M. Tollenaar,Katarzyna Durda,Katarzyna Jaworska,Katarzyna Jaworska,Jaana M. Hartikainen,Veli-Matti Kosma,Vesa Kataja,Natalia Antonenkova,Jirong Long,Martha J. Shrubsole,Sandra Deming-Halverson,Artitaya Lophatananon,Artitaya Lophatananon,Pornthep Siriwanarangsan,Sarah Stewart-Brown,Nina Ditsch,Peter Lichtner,Rita K. Schmutzler,Hidemi Ito,Hiroji Iwata,Kazuo Tajima,Chiu-Chen Tseng,Daniel O. Stram,David Van Den Berg,Cheng Har Yip,M. Kamran Ikram,Yew Ching Teh,Hui Cai,Wei Lu,Lisa B. Signorello,Qiuyin Cai,Dong Young Noh,Keun-Young Yoo,Hui Miao,Philip Iau,Yik Ying Teo,James McKay,Charles L. Shapiro,Foluso O. Ademuyiwa,George Fountzilas,Chia-Ni Hsiung,Jyh Cherng Yu,Ming-Feng Hou,Catherine S. Healey,Craig Luccarini,Susan Peock,Dominique Stoppa-Lyonnet,Paolo Peterlongo,Timothy R. Rebbeck,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Kenneth Offit,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Judy Garber,Steven A. Narod,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Evgeny N. Imyanitov,Laima Tihomirova,Banu Arun,Ian G. Campbell,Arjen R. Mensenkamp,Christi J. van Asperen,Kees E. P. van Roozendaal,Hanne Meijers-Heijboer,J. Margriet Collée,Jan C. Oosterwijk,Maartje J. Hooning,Matti A. Rookus,Rob B. van der Luijt,Theo A. Mvan Os,D. Gareth Evans,Debra Frost,Elena Fineberg,Julian Barwell,Lisa Walker,M. John Kennedy,Radka Platte,Rosemarie Davidson,Steve Ellis,Trevor Cole,Brigitte Bressac-de Paillerets,Bruno Buecher,Francesca Damiola,Laurence Faivre,Marc Frenay,Olga M. Sinilnikova,Olivier Caron,Sophie Giraud,Sylvie Mazoyer,Valérie Bonadona,Virginie Caux-Moncoutier,Aleksandra Tołoczko-Grabarek,Jacek Gronwald,Tomasz Byrski,Amanda B. Spurdle,Bernardo Bonanni,Daniela Zaffaroni,Giuseppe Giannini,Loris Bernard,Riccardo Dolcetti,Siranoush Manoukian,Norbert Arnold,Christoph Engel,Helmut Deissler,Kerstin Rhiem,Dieter Niederacher,Hansjoerg Plendl,Christian Sutter,Barbara Wappenschmidt,Åke Borg,Beatrice Melin,Johanna Rantala,Maria Soller,Katherine L. Nathanson,Susan M. Domchek,Gustavo C. Rodriguez,Ritu Salani,Daphne Gschwantler Kaulich,Muy Kheng Tea,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Torben A Kruse,Uffe Birk Jensen,Mark E. Robson,Anne-Marie Gerdes,Bent Ejlertsen,Lenka Foretova,Sharon A. Savage,Jenny Lester,Penny Soucy,Karoline Kuchenbaecker,Curtis Olswold,Julie M. Cunningham,Susan L. Slager,Vernon S. Pankratz,Ed Dicks,Sunil R. Lakhani,Sunil R. Lakhani,Fergus J. Couch,Per Hall,Alvaro N.A. Monteiro,Simon A. Gayther,Paul D.P. Pharoah,Roger R. Reddel,Roger R. Reddel,Ellen L. Goode,Mark H. Greene,Douglas F. Easton,Andrew Berchuck,Antonis C. Antoniou,Georgia Chenevix-Trench,Alison M. Dunning +455 more
TL;DR: Using the Illumina custom genotyping array iCOGs, SNPs at the TERT locus in breast, ovarian and BRCA1 mutation carrier cancer cases and controls and leukocyte telomere measurements are analyzed to find associations cluster into three independent peaks.