L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
Papers
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Journal ArticleDOI
Insights from the architecture of the bacterial transcription apparatus
TL;DR: A portrait of the bacterial transcription apparatus is provided in light of the data emerging from structural studies, sequence analysis and comparative genomics to bring out important but underappreciated features and some of the interesting evolutionary conundrums posed by the newly gained understanding.
Journal ArticleDOI
The natural history of ubiquitin and ubiquitin-related domains.
TL;DR: Recent comparative genomics studies indicate precursors of the eukaryotic Ub-system emerged in prokaryotes, and Sampylation in archaea and Urmylation in Eukaryotes appear to represent recruitment of such systems as simple protein-tagging apparatuses.
Journal ArticleDOI
Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase
TL;DR: It is shown that double-stranded β-helix dioxygenases diversified extensively in biosynthesis and modification of halogenated siderophores, antibiotics, peptide secondary metabolites and glycine-rich collagen-like proteins in bacteria.
Journal ArticleDOI
Origin of multicellular eukaryotes - insights from proteome comparisons.
L. Aravind,G Subramanian +1 more
TL;DR: Comparisons of the complete genomes of the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans reveal some striking trends in terms of expansions or extensive shuffling of specific domains that are involved in regulatory functions and signaling.
Book ChapterDOI
Methods to reconstruct and compare transcriptional regulatory networks.
TL;DR: This chapter describes methods to reconstruct and analyze the transcriptional regulatory networks of uncharacterized organisms by using a known regulatory network as a template.