L. Aravind

TL;DR: A previously uncharacterized 110-125 residue-long domain was identified both in the physiologically important enzyme dopamine beta-monooxygenase and in several other secreted and transmembrane proteins such as SDR2 and CG-6.

TL;DR: It is found that CD14 plays a predominant role in the induction of ECM and regulation of parasite density; deletion of the CD14 gene not only prevented the onset of disease in a majority of susceptible mice, but also had an ameliorating effect on parasitemia.

TL;DR: Evidence is presented that members of this superfamily are likely to bind a range of soluble ligands, including B12, and this might be correlated with the emergence of the ability to utilize B12 produced by gut bacteria.

TL;DR: It is suggested that the higher expression of hemoglobin α1 in the brain may be associated with ECM and could be a source of excess heme, a molecule that is considered to trigger the pathogenesis of CM.

TL;DR: It is shown that despite considerable structural diversity in the fold, its representatives show a common mode of nucleic acid or nucleotide interaction via the exposed face of the sheet, and is presented evidence for a bacterial origin of the GYF domain and proposed how this version of the fold might have been utilized in peptide interactions in the context of nucleoprotein complexes.