L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
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Journal ArticleDOI
Differential action of natural selection on the N and C-terminal domains of 2'-5' oligoadenylate synthetases and the potential nuclease function of the C-terminal domain.
TL;DR: Comparative sequence analysis of OAS, poly(A)-polymerases, TRF4/sigma-family polymerases, archaeal CCA-adding enzymes and uridilyltransferases from trypanosomes resulted in the identification of a C-terminal domain, which is conserved in all these enzymes and is distinct from the nucleotidyltransferase domain.
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Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations.
A. Maxwell Burroughs,L. Aravind +1 more
TL;DR: 12 new prokaryotic immune systems are identified, which are unify by this principle of threshold-dependent effector activation, which is established to be a more general principle of immune systems, which can also operate independently of such messengers.
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Resilience of biochemical activity in protein domains in the face of structural divergence
TL;DR: Intense selective pressures from 'arms-race'-like situations in conflict and macromolecular modification systems could favor drastic structural divergence while preserving function.
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Provenance of SET-domain histone methyltransferases through duplication of a simple structural unit.
TL;DR: The SET domain provides a model for the innovation of a complex enzymatic fold through the duplications of a structurally simple non-enzymatic unit and represents a case of convergent evolution of an active-site-associated configuration in two otherwise unrelated classes of methylases.
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Jumbo Phages: A Comparative Genomic Overview of Core Functions and Adaptions for Biological Conflicts.
Lakshminarayan M. Iyer,Vivek Anantharaman,Arunkumar Krishnan,A. Maxwell Burroughs,L. Aravind +4 more
TL;DR: In this paper, a comparative genomics analysis of 224 jumbo phages was performed and an objective inclusion criterion based on genome size distributions was suggested, and a synthetic overview of their manifold adaptations across major biological systems was presented.