L. Aravind

TL;DR: In this paper, the authors systematically analyzed prokaryotic Ub-related β-grasp fold proteins using sensitive sequence profile searches and structural analysis, and identified novel Ubrelated proteins beyond the characterized ThiS, MoaD, TGS, and YukD domains.

TL;DR: It is found that PCIF1 binds and is dependent on the m7G cap, and the accurate mapping technique will facilitate future studies to characterize m6Am's function.

TL;DR: Comparative analysis of numerous protein structures that have become available in the past few years, combined with genome comparison, has yielded new insights into the evolution of enzymes and their functions, revealing biochemical plasticity of a fold seems to hinge on the presence of a generic, symmetrical substrate-binding pocket as opposed to highly specialized binding sites.

TL;DR: It is shown that the SpoU superfamily encompasses a greater diversity of (predicted) methylases than previously appreciated and contains two previously undetected families that are specific to the archaea and thermophilic bacteria.