L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
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Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins.
TL;DR: The common ancestor of all life forms could encode a prototype Toprim enzyme that might have had both nucleotidyl transferase and polynucleotide cleaving activity, supported by site-directed mutagenesis data on primases and Topo IA.
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Construction and analysis of bacterial artificial chromosome libraries from a marine microbial assemblage
Oded Béjà,Marcelino T. Suzuki,Eugene V. Koonin,L. Aravind,Andrew G. Hadd,Linh Nguyen,Rachel Villacorta,Mojgan Amjadi,Corey Garrigues,Stevan B. Jovanovich,Robert A. Feldman,Edward F. DeLong +11 more
TL;DR: The results verify the utility of BAC libraries for providing access to the genomes of as yet uncultivated microbial species and investigate the genomic potential and ecological roles of many indigenous microbial species, cultivated or not.
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Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes
Vivek Anantharaman,L. Aravind +1 more
TL;DR: The predicted structural features indicate that the N1pC/P60 enzymes contain a fold similar to the papain-like peptidases, transglutaminases and arylamine acetyltransferases, as well as several related, but distinct, catalytic activities, such as murein degradation, acyl transfer and amide hydrolysis, have emerged in this superfamily.
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Apoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome Comparisons
TL;DR: A comparison of the proteins encoded in the recently (nearly) completed human genome to those from the fly and nematode genomes reveals a major increase in the complexity of the apoptotic molecular machinery in vertebrates, in terms of both the number of proteins involved and their domain architecture.
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Plasmodium biology: genomic gleanings.
TL;DR: The highly A+T rich genomes of human and rodent malarial parasites offer unprecedented glimpses of a lineage that is distinct from other model organisms.