L. Aravind

TL;DR: Contextual analysis indicates that the bacteriophage versions of ADPr-targeting domains are more likely to counter soluble ADPr derivatives, while the eukaryotic RNA viral versions might prefer macromolecular ADPr adducts, and comparative genomics is used to predict host systems involved in countering viral ADP ribosylation of host molecules.

TL;DR: In this article, the authors describe a T6SS-dependent delivery mechanism for a subset of Rhs proteins that lack a PAAR motif, and show that the mechanism requires removal of an N-terminal fragment by auto-proteolysis, followed by interaction with PAAR protein and then secretion.

TL;DR: It is shown that the M and ORF3 are under differential evolutionary pressures; in contrast to the slow evolution of M as core structural component, the CoV-ORF3 clade is under selection for diversification, which indicates it is likely at the interface with host molecules and/or immune attack.

TL;DR: Koonin and Aravind as discussed by the authors published a highly cited paper published in Cell Cycle: Vol. 8, No. 13, pp. 1984-1985, as discussed by the authors.

TL;DR: It is shown that genetic interactions between components of a receptor-like ubiquitin ligase complex that tunes morphogen signaling strength can cause a birth defect syndrome inherited in an oligogenic pattern.