L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
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Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant
Lurdes Queimado,Malini Rao,Roger A. Schultz,Eugene V. Koonin,L. Aravind,Tiziana Nardo,Miria Stefanini,Errol C. Friedberg +7 more
TL;DR: The molecular cloning of human and mouse orthologs of the yeast MMS19 gene indicates functional conservation between the yeast and mammalian gene products and suggests a role of Mms19 protein in the assembly of a multiprotein complex required for NER and RNAP II transcription.
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Molecular Correlates of Experimental Cerebral Malaria Detectable in Whole Blood
Miranda S. Oakley,Vivek Anantharaman,Thiago M. Venancio,Hong Zheng,Babita Mahajan,Victoria Majam,Thomas F. McCutchan,Timothy G. Myers,L. Aravind,Sanjai Kumar +9 more
TL;DR: These studies provide the first host transcriptome database that is uniquely altered during the pathogenesis of ECM in blood, as measured by quantitative real-time PCR analysis.
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Oxidative opening of the aromatic ring: Tracing the natural history of a large superfamily of dioxygenase domains and their relatives.
TL;DR: Light is thrown on the functions of large swaths of the experimentally-uncharacterized PCAD–Memo families, extending known conserved contextual associations for the Memo clade beyond previously-described associations with the AMMECR1 domain and a radical S-adenosylmethionine family domain.
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The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis.
Changqing Zhang,Yu-Hung Hung,Hyun Jung Rim,Dapeng Zhang,Jennifer M. Frost,Hosub Shin,Hosung Jang,Fang Liu,Fang Liu,Wenyan Xiao,Lakshminarayan M. Iyer,L. Aravind,Xiang-Qian Zhang,Xiang-Qian Zhang,Robert L. Fischer,Jin Hoe Huh,Tzung-Fu Hsieh +16 more
TL;DR: A bipartite model for DME protein action is proposed and it is suggested that the DME N terminus was acquired late during land plant evolution to improve specificity and facilitate demethylation at heterochromatin targets.
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Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis
A. Maxwell Burroughs,L. Aravind +1 more
TL;DR: Significant evidence is provided for “systems admixture,” which followed the early endosymbiotic event, playing a key role in the emergence of the uniquely eukaryotic ribosome biogenesis process.