L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
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Journal ArticleDOI
Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans
TL;DR: In this article, the authors used sensitive sequence analysis and comparative genomics methods to identify unambiguous bacterial homologs of the Death-like and TRADD-N superfamilies, a quintessential feature of metazoan apoptotic systems.
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Erratum: Corrigendum: Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
Andy L Johnson,L. Aravind,Natalia Shulzhenko,Andre Morgun,Seeyoung Choi,Tanya L. Crockford,Teresa Lambe,Heather Domaschenz,Edyta M. Kucharska,Lixin Zheng,Carola G. Vinuesa,Michael J. Lenardo,Christopher C. Goodnow,Richard J. Cornall,Ronald H. Schwartz +14 more
TL;DR: In the version of this article initially published, the top right graph in Figure 7b is incorrect, and the error has been corrected in the HTML and PDF versions of the article.
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Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens.
Nitin Verma,Ankit Puri,Edward Essuman,Richard A. Skelton,Vivek Anantharaman,Hong Zheng,Siera White,Karthigayan Gunalan,Kazuyo Takeda,Surabhi Bajpai,Timothy J. Lepore,Peter J. Krause,L. Aravind,Sanjai Kumar +13 more
TL;DR: Using genome-wide immunoscreening and extensive computational sequence and bioinformatics analyses and cellular localization studies, the domain architectures, potential biological functions, and evolutionary relationships of the most immunodominant B. microti antigens are clarified and can be evaluated to develop novel assays and candidate vaccines.
Journal ArticleDOI
Erratum: Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (14936-14941) DOI 10.1073/pnas.1506226112)
Rafael D. Mesquita,Raquel J. Vionette-Amaral,Carl Lowenberger,Rolando Rivera-Pomar,Fernando A. Monteiro,Patrick Minx,John Spieth,A. Bernardo Carvalho,Francisco Panzera,Daniel Lawson,André Q. Torres,André Q. Torres,José M. C. Ribeiro,Marcos Henrique Ferreira Sorgine,Robert M. Waterhouse,Michael J. Montague,Fernando Abad-Franch,Michele Alves-Bezerra,Laurence Rodrigues do Amaral,Helena Araujo,Ricardo Nascimento Araújo,L. Aravind,Georgia C. Atella,Patrícia Azambuja,Mateus Berni,Paula R. Bittencourt-Cunha,Glória R.C. Braz,Gustavo M. Calderón-Fernández,Claudia M. A. Carareto,Mikkel B. Christensen,Igor Rodrigues da Costa,Samara G. da Costa,Marilvia Dansa,Carlos R. O. Daumas-Filho,Iron F. De-Paula,Felipe A. Dias,George Dimopoulos,Scott J. Emrich,Natalia Esponda-Behrens,Patrícia Fampa,Rita D. Fernandez-Medina,Rodrigo Nunes da Fonseca,Marcio Fontenele,Catrina Fronick,Lucinda Fulton,Ana Caroline P. Gandara,Eloi S. Garcia,Fernando A. Genta,Gloria I. Giraldo-Calderón,Bruno Gomes,Katia C. Gondim,Adriana Granzotto,Alessandra A. Guarneri,Roderic Guigó,Myriam Harry,Myriam Harry,Daniel S.T. Hughes,Willy Jablonka,Emmanuelle Jacquin-Joly,M. Patricia Juárez,Leonardo Koerich,Angela B. Lange,Jose Manuel Latorre-Estivalis,Andrés Lavore,Gena G. Lawrence,Cristiano Lazoski,Claudio R. Lazzari,Raphael R.S. Lopes,Marcelo G. Lorenzo,Magda D. Lugon,David Majerowicz,Paula L. Marcet,Marco Mariotti,Hatisaburo Masuda,Karyn Megy,Ana C.A. Melo,Fanis Missirlis,Theo Mota,Fernando G. Noriega,Marcela Nouzova,Rodrigo Dutra Nunes,Raquel L.L. Oliveir,Gilbert Oliveira-Silveira,Sheila Ons,Ian Orchard,Lucia Pagola,Gabriela O. Paiva-Silva,Agustina Pascual,Márcio G. Pavan,Nicolás Pedrini,Alexandre A. Peixoto,Marcos H. Pereira,Andrew Pike,Carla Polycarpo,Francisco Prosdocimi,Rodrigo Ribeiro-Rodrigues,Hugh M. Robertson,Ana Paula Salerno,Didier Salmon,Didac Santesmasses,Renata Schama,Eloy S. Seabra,Lívia Silva-Cardoso,Mário A.C. Silva-Neto,Matheus Souza-Gomes,Marcos Sterkel,Mabel L. Taracena,Marta Tojo,Zhijian Jake Tu,Jose M. C. Tubio,Raul Ursic-Bedoya,Thiago M. Venancio,Ana Beatriz Walter-Nuno,Derek J. Wilson,Wesley C. Warren,Richard K. Wilson,Erwin Huebner,Ellen M. Dotson,Pedro L. Oliveira +118 more
Journal ArticleDOI
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer
Eun Myoung Shin,Vinh Thang Huynh,Vinh Thang Huynh,Sultan Abda Neja,Chia Yi Liu,Anandhkumar Raju,Kelly Tan,Nguan Soon Tan,Jayantha Gunaratne,Jayantha Gunaratne,Xuezhi Bi,Xuezhi Bi,Lakshminarayan M. Iyer,L. Aravind,Vinay Tergaonkar,Vinay Tergaonkar +15 more
TL;DR: The authors showed that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residues T553/S554, which stabilizes ERα protein by inhibiting association with the ubiquitin ligase ZNF598.