L. Aravind

TL;DR: The complete sequence of the GC-rich genome of Methanopyrus kandleri is determined by using a whole direct genome sequencing approach and indicates that archaeal methanogens are monophyletic.

TL;DR: It is shown that prokaryotic transcriptional regulatory networks have evolved principally through widespread tinkering of transcriptional interactions at the local level by embedding orthologous genes in different types of regulatory motifs, suggesting that organisms with similar lifestyles across a wide phylogenetic range tend to conserve equivalent interactions and network motifs.

TL;DR: The problem of the genome–phenotype connection, which, in a sense, is the central theme of biology, can be solved only through an experimental program strategically planned on the basis of comparative-genomic results.

TL;DR: A comprehensive database of bacterial lipoproteins is created, called DOLOP, which contains information and links to molecular details for about 278 distinct lipo-molecular details and predicted lipiproteins from 234 completely sequenced bacterial genomes and features a tool that applies a predictive algorithm to identify the presence or absence of the lipoprotein signal sequence in a user-given sequence.

TL;DR: Lamprey lymphocytes express two putative deaminases of the AID-APOBEC family that may be involved in VLR diversification, as indicated by in vitro mutagenesis and recombination assays.