L
L. Aravind
Researcher at National Institutes of Health
Publications - 401
Citations - 88329
L. Aravind is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Protein domain. The author has an hindex of 127, co-authored 388 publications receiving 81679 citations. Previous affiliations of L. Aravind include Texas A&M University & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells.
Vipul Shukla,Levon Halabelian,Sanjana Balagere,Daniela Samaniego-Castruita,Douglas E. Feldman,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Anjana Rao,Anjana Rao,Anjana Rao,L. Aravind +11 more
TL;DR: It is shown here that Hmces-deficient mice display normal hematopoiesis without global alterations in 5hmC, and a potential structural basis for the interaction of HMCES with long DNA overhangs generated by Alt-EJ during CSR is provided.
Journal ArticleDOI
The Histone Database: a comprehensive WWW resource for histones and histone fold-containing proteins
TL;DR: The Histone Database (HDB) is an annotated and searchable collection of all full-length sequences and structures of histone and non-histone proteins containing the histone fold motif.
Journal ArticleDOI
Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease.
TL;DR: A function for a class of DNA base modification-selective nucleases and position Srap1 as a determinant of 5mC demethylation trajectories during mammalian embryonic development are established.
Journal ArticleDOI
Selection of the lamprey VLRC antigen receptor repertoire
Stephen J. Holland,Mingming Gao,Masayuki Hirano,Lakshminarayan M. Iyer,Ming Luo,Ming Luo,Michael Schorpp,Max D. Cooper,L. Aravind,Roy A. Mariuzza,Thomas Boehm +10 more
TL;DR: Significant signatures for selection of the VLRC receptors that are expressed by one of the T-cell lineages of lamprey are identified; selection concerns the length of the receptor molecules and their N-terminal sequence diversity, and these findings pave the way to identifying the mechanistic basis of selection.
Journal ArticleDOI
The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies
Vivek Anantharaman,L. Aravind +1 more
TL;DR: The SHS2 domain is an example of a simple module that has been adapted to perform an entire spectrum of functions ranging from protein–protein interactions to small‐molecule recognition and catalysis, and is predicted to be important for ligand specificity in the GyrI superfamily.