L
Lance D. Miller
Researcher at Wake Forest University
Publications - 208
Citations - 16169
Lance D. Miller is an academic researcher from Wake Forest University. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 58, co-authored 195 publications receiving 14459 citations. Previous affiliations of Lance D. Miller include University of Texas MD Anderson Cancer Center & East Carolina University.
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Journal ArticleDOI
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Chin-Yo Lin,Anders Ström,Vinsensius B. Vega,Say Li Kong,Ai Li Yeo,Jane S. Thomsen,Wan Ching Chan,Balraj Doray,Dhinoth Kumar Bangarusamy,Adaikalavan Ramasamy,Liza A Vergara,Suisheng Tang,Allen Chong,Vladimir B. Bajic,Lance D. Miller,Jan-Åke Gustafsson,Edison T. Liu +16 more
TL;DR: Only a small core set of human genes appear to be sufficient to induce ER effects in breast cancer cells, and that cis-regulatory regions of these core ER target genes are poorly conserved suggests that different evolutionary mechanisms are operative at transcriptional control elements than at coding regions.
Journal ArticleDOI
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Siew Hong Lam,Yi Lian Wu,Vinsensius B. Vega,Lance D. Miller,Jan M. Spitsbergen,Yan Tong,Huiqing Zhan,Kunde R Govindarajan,Serene Lee,Sinnakarupan Mathavan,Karuturi R. Krishna Murthy,Donald R. Buhler,Edison T. Liu,Zhiyuan Gong +13 more
TL;DR: Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors, providing a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
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Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients.
Stefano Calza,Stefano Calza,Per Hall,Gert Auer,Judith Bjöhle,Sigrid Klaar,Ulrike Kronenwett,Edison T. Liu,Lance D. Miller,Alexander Ploner,Johanna Smeds,Jonas Bergh,Yudi Pawitan +12 more
TL;DR: The intrinsic gene set, originally selected to reveal stable tumor characteristics, was shown to have a strong correlation with progression-related properties such as grade, p53 mutation and genomic instability.
Journal Article
Prospective Molecular Profiling of Melanoma Metastases Suggests Classifiers of Immune Responsiveness
Ena Wang,Lance D. Miller,Galen A. Ohnmacht,Simone Mocellin,Ainhoa Perez-Diez,David Petersen,Yingdong Zhao,Richard Simon,John Powell,Esther Asaki,H. Richard Alexander,Paul H. Duray,Meenhard Herlyn,Nicholas P. Restifo,Edison T. Liu,Steven A. Rosenberg,Francesco M. Marincola +16 more
TL;DR: Ranking of gene expression data from pretreatment samples identified approximately 30 genes predictive of clinical response, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition.
Journal ArticleDOI
Iron addiction: a novel therapeutic target in ovarian cancer
Debargha Basuli,Lia Tesfay,Zhiyong Deng,Bibbin T. Paul,Yusuke Yamamoto,Gang Ning,Wa Xian,Frank McKeon,Miranda L. Lynch,Christopher P. Crum,Poornima Hegde,Molly Brewer,Xiaohong Wang,Lance D. Miller,Nathaniel A. Dyment,Frank M. Torti,Suzy V. Torti +16 more
TL;DR: The iron dependence of ovarian cancer TICs renders them exquisitely sensitive in vivo to agents that induce iron-dependent cell death (ferroptosis) as well as iron chelators, and thus creates a metabolic vulnerability that can be exploited therapeutically.