Lance D. Miller

TL;DR: The studies show that DEC1 is involved in esophageal cancer development and help elucidate its functional role in tumor development and show statistically significant differences in colony numbers with the vector‐alone controls.

TL;DR: Human breast epithelial cells/cancer cells with wild-type p53 were sensitive to growth inhibition by activated Dmp1:ER while those that delete p14ARF or p53, and/or Hdm2 amplification showed partial or nearly complete resistance, indicating that p53 is a critical target for hDMP1 to exhibit its biological activity.

TL;DR: Light is shed on an immune escape mechanism driven by activin A and dual targeting of activation A and TGFβ may be required to optimally unleash radiation-induced antitumor immunity against breast cancer, and retrospective analysis of a public dataset of patients with breast cancer revealed a positive correlation betweenactivin A gene expression and Treg abundance.

TL;DR: The results show that the proposed statistic provides a more powerful basis for gene selection than the classical Cox model-based statistic and many of the genes identified here as associated with the speed of disease recurrence have known roles in tumorigenesis.

TL;DR: Results suggest that the tumor-suppressing effect is not attributed to RB1, but instead likely involves thrombospondin type I domain-containing 1 (THSD1), a novel candidate TSG mapping to 13q14.