L
Lei Zhang
Researcher at Central South University
Publications - 694
Citations - 15023
Lei Zhang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 51, co-authored 588 publications receiving 11345 citations. Previous affiliations of Lei Zhang include Monash University & Kirby Institute.
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DeepHINT: understanding HIV-1 integration via deep learning with attention.
Hailin Hu,An Xiao,Sai Zhang,Yangyang Li,Xuanling Shi,Tao Jiang,Tao Jiang,Linqi Zhang,Lei Zhang,Jianyang Zeng +9 more
TL;DR: In-depth analyses of the attention values output by DeepHINT revealed intriguing mechanistic implications in the selection of HIV integration sites, including potential roles of several DNA-binding proteins.
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Neuromyelitis optica spectrum disorders without and with autoimmune diseases
TL;DR: The characteristics between NMOSD without and with autoimmune diseases were similar andNMOSD patients with autoimmune Diseases had higher brain abnormalities than NMOSS without autoimmune diseases.
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Modelling the Epidemiological Impact and Cost-Effectiveness of PrEP for HIV Transmission in MSM in China
Lei Zhang,Lei Zhang,Peng Peng,Yumeng Wu,Xiaomeng Ma,Nyi Nyi Soe,Xiaojie Huang,Hao Wu,Martin Markowitz,Kathrine Meyers +9 more
TL;DR: The cost of daily oral Truvada PrEP regimen would need to be reduced by half to achieve cost-effectiveness and realize the public health good of preventing hundreds of thousands of HIV infections among MSM in China.
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Transcription factors acting on the promoter of the rat fatty acid synthase gene
TL;DR: It was shown that Sp1 and NF-Y interact co-operatively at the diet-induced DNase I-hypersensitive site at position -500 and both FIRE3 and ICE are also necessary for the response to retinoic acid that plays a role in development and is an essential component of the diet.
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SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2
TL;DR: It is demonstrated that RXR ligands can stimulate the expression of a lipogenic gene solely by inducing transcription and cleavage of membrane‐bound SREBP‐1c.