Lei Zhang

TL;DR: In this article, the authors examine le effets et les mecanismes de Mycobacterium smegmatis recombinant (rMS) porteur du pZM03 (un plasmide de co-expression encodant la granulysine [GLS] humaine and l'interleukine 12 [IL-12] murin) sur l'infection murine par M. tuberculosis.

TL;DR: The AZTEC trial aims to determine if a 10-day early course of intravenous azithromycin improves rates of survival without CLD when compared with placebo with an appropriately powered study.

TL;DR: In this article, the authors proposed strategies suggested by the World Health Organization (WHO) which have been proven useful in China to combat the COVID-19 pandemic and implemented them in countries with different situations.

TL;DR: It has been demonstrated that a new virtual screening approach with accelerated free energy perturbation-based absolute binding free energy (FEP-ABFE) predictions can reach an unprecedently high hit rate, leading to successful identification of 16 potent inhibitors of SARS-CoV-2 main protease (Mpro) from computationally selected 25 drugs under a threshold of Ki = 4 μM.

TL;DR: A transition point from a slow- to a fast-growing phase for COVID-19 is identified at 5.5 days after the first report, and 30 confirmed cases marked a critical threshold for this transition, which is highly correlated with the actual ranking of epidemic size.