Lennart Opitz

TL;DR: Targeting cellular redox balance might qualify as a potential pharmacotherapeutic approach to improve neuronal network function in Rett syndrome.

TL;DR: It is proposed that upregulation of hsa-miR-342-3p may be a general phenomenon in late stage prion disease and might be used as a novel marker for animal and human TSEs.

TL;DR: It is demonstrated that sperm tsRNA is a potential vector that contributes to the transmission of MHFD-induced addictive-like behaviors and obesogenic phenotypes across generations, thereby emphasizing its role in diverse pathological outcomes.

TL;DR: In models of stored blood transfusion and hemoglobin (Hb) exposure in guinea pigs and beagle dogs, experiments confirmed that free heme is a likely trigger of tubule barrier deregulation and oxidative cell damage and reinforced the hypothesis that uncontrolledfree heme could trigger the UPR as an important pathway of renal injury during hemoglobinuria.

TL;DR: It is shown that diffuse large B-cell lymphomas possess a self-organized infrastructure comprising side population (SP) and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt signaling.