L
Leonardo Cruz de Souza
Researcher at Universidade Federal de Minas Gerais
Publications - 184
Citations - 9362
Leonardo Cruz de Souza is an academic researcher from Universidade Federal de Minas Gerais. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 33, co-authored 146 publications receiving 7360 citations. Previous affiliations of Leonardo Cruz de Souza include French Institute of Health and Medical Research & University of Paris.
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Journal ArticleDOI
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Bruno Dubois,Bruno Dubois,Howard Feldman,Claudia Jacova,Harald Hampel,Harald Hampel,José Luis Molinuevo,Kaj Blennow,Steven T. DeKosky,Serge Gauthier,Dennis J. Selkoe,Randall J. Bateman,Stefano F. Cappa,Sebastian J. Crutch,Sebastiaan Engelborghs,Giovanni B. Frisoni,Nick C. Fox,Douglas Galasko,Marie-Odile Habert,Gregory A. Jicha,Agneta Nordberg,Florence Pasquier,Gil D. Rabinovici,Philippe Robert,Christopher C. Rowe,Stephen Salloway,Marie Sarazin,Stéphane Epelbaum,Stéphane Epelbaum,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Leonardo Cruz de Souza,Bruno Vellas,Pieter Jelle Visser,Lon S. Schneider,Yaakov Stern,Philip Scheltens,Jeffrey L. Cummings +37 more
TL;DR: It is proposed that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease.
Journal ArticleDOI
Revising the definition of Alzheimer's disease: a new lexicon.
Bruno Dubois,Howard Feldman,Howard Feldman,Howard Feldman,Claudia Jacova,Jeffrey L. Cummings,Steven T. DeKosky,Pascale Barberger-Gateau,André Delacourte,Giovanni B. Frisoni,Nick C. Fox,Douglas Galasko,Serge Gauthier,Harald Hampel,Gregory A. Jicha,Kenichi Meguro,John T. O'Brien,Florence Pasquier,Philippe Robert,Martin N. Rossor,Steven Salloway,Marie Sarazin,Leonardo Cruz de Souza,Yaakov Stern,Pieter Jelle Visser,Pieter Jelle Visser,Philip Scheltens +26 more
TL;DR: This paper aims to advance the scientific discussion by providing broader diagnostic coverage of the AD clinical spectrum and by proposing a common lexicon as a point of reference for the clinical and research communities.
Journal ArticleDOI
Consensus classification of posterior cortical atrophy
Sebastian J. Crutch,Jonathan M. Schott,Gil D. Rabinovici,Melissa E. Murray,Julie S. Snowden,Julie S. Snowden,Wiesje M. van der Flier,Bradford C. Dickerson,Rik Vandenberghe,Samrah Ahmed,Thomas H. Bak,Bradley F. Boeve,Christopher C Butler,Stefano F. Cappa,Mathieu Ceccaldi,Leonardo Cruz de Souza,Bruno Dubois,Olivier Felician,Douglas Galasko,Jonathan Graff-Radford,Neill R. Graff-Radford,Patrick R. Hof,Pierre Krolak-Salmon,Manja Lehmann,Manja Lehmann,Eloi Magnin,Mario F. Mendez,Peter J. Nestor,Chiadi U. Onyike,Victoria S. Pelak,Yolande A.L. Pijnenburg,Silvia Primativo,Martin N. Rossor,Natalie S. Ryan,Philip Scheltens,Timothy J. Shakespeare,Aida Suarez Gonzalez,David F. Tang-Wai,Keir X.X. Yong,Maria C. Carrillo,Nick C. Fox +40 more
TL;DR: A classification framework for posterior cortical atrophy (PCA) is proposed to improve the uniformity of definition of the syndrome in a variety of research settings.
Journal ArticleDOI
Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging.
Lorraine Hamelin,Lorraine Hamelin,Julien Lagarde,Guillaume Dorothée,Guillaume Dorothée,Claire Leroy,Mickael Labit,Robert A. Comley,Leonardo Cruz de Souza,Hélène Corne,Luce Dauphinot,Maxime Bertoux,Maxime Bertoux,Bruno Dubois,Philippe Gervais,Olivier Colliot,Marie-Claude Potier,Michel Bottlaender,Marie Sarazin +18 more
TL;DR: Microglial activation appears at the prodromal and possibly at the preclinical stage of Alzheimer's disease, and seems to play a protective role in the clinical progression of the disease at these early stages, according to a second-generation 18-kDa translocator protein positron emission tomography radiotracer.
Journal ArticleDOI
Alzheimer's disease: risk factors and potentially protective measures.
Marcos Vinícius Ferreira Silva,Cristina de Mello Gomide Loures,Luan Carlos Vieira Alves,Leonardo Cruz de Souza,Karina Braga Gomes Borges,Maria das Graças Carvalho +5 more
TL;DR: The aim of the present minireview was to summarize the pathophysiological mechanism and the main risk factors for AD, and some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.